A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan

Etsuro Nanishi, Takayuki Hoshina, Masafumi Sanefuji, Ryo Kadoya, Katsuhiko Kitazawa, Yukie Arahata, Tetsuya Sato, Yoshimichi Hirayama, Katsuki Hirai, Masaaki Yanai, Kaori Nikaido, Akihiko Maeda, Hiroyuki Torisu, Kenji Okada, Yasunari Sakai, Shoichi Ohga

研究成果: ジャーナルへの寄稿記事

抄録

BACKGROUND: Japanese encephalitis (JE) is the leading cause of viral encephalitis with high mortality and morbidity in Asia. In Japan, however, the active recommendation of JE vaccine was retracted in 2005 because of the potential risk of acute disseminated encephalomyelitis. We aimed to determine the recent incidence of childhood-onset JE after the domestic change of vaccination policy in Japan, and to analyze the clinical features of affected children. METHODS: A retrospective nationwide survey was conducted for pediatric patients with JE in Japan from 1995 to 2015. The national surveillance system was used to identify the pediatric patients with JE. Follow-up questionnaires were sent to analyze their clinical and neuroimaging profiles. RESULTS: Among a total of 109 patients registered to the national surveillance, 10 (9%) were less than age 15 years. The annual incidence rate of childhood-onset JE was higher during 2005-15 than that during 1995-2004 (4.3 × 10-3 vs 1.1 × 10-3 per 100000, respectively; P = .04). Endemic regions overlapped with prefectures that farmed pigs harboring antibodies against JE virus with high prevalence. Detailed clinical data were collected from 9 patients. None of them died, but 5 of 9 patients (56%) had neurological sequelae after recovery. One patient who was partially vaccinated with 2 doses of JE vaccine fully recovered from a coma. The age of 3 years or less was associated with unfavorable neurological prognosis. CONCLUSIONS: Our data provide evidence for the importance and prophylactic effect of the JE vaccine in young children in the endemic area.

元の言語英語
ページ(範囲)2099-2104
ページ数6
ジャーナルClinical infectious diseases : an official publication of the Infectious Diseases Society of America
68
発行部数12
DOI
出版物ステータス出版済み - 5 30 2019

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Japanese Encephalitis
Japan
Japanese Encephalitis Vaccines
Pediatrics
Japanese Encephalitis Virus
Acute Disseminated Encephalomyelitis
Viral Encephalitis
Incidence
Coma
Neuroimaging
Surveys and Questionnaires
Vaccination
Swine
Morbidity
Mortality
Antibodies

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

これを引用

A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan. / Nanishi, Etsuro; Hoshina, Takayuki; Sanefuji, Masafumi; Kadoya, Ryo; Kitazawa, Katsuhiko; Arahata, Yukie; Sato, Tetsuya; Hirayama, Yoshimichi; Hirai, Katsuki; Yanai, Masaaki; Nikaido, Kaori; Maeda, Akihiko; Torisu, Hiroyuki; Okada, Kenji; Sakai, Yasunari; Ohga, Shoichi.

:: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 巻 68, 番号 12, 30.05.2019, p. 2099-2104.

研究成果: ジャーナルへの寄稿記事

Nanishi, E, Hoshina, T, Sanefuji, M, Kadoya, R, Kitazawa, K, Arahata, Y, Sato, T, Hirayama, Y, Hirai, K, Yanai, M, Nikaido, K, Maeda, A, Torisu, H, Okada, K, Sakai, Y & Ohga, S 2019, 'A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 巻. 68, 番号 12, pp. 2099-2104. https://doi.org/10.1093/cid/ciy816
Nanishi, Etsuro ; Hoshina, Takayuki ; Sanefuji, Masafumi ; Kadoya, Ryo ; Kitazawa, Katsuhiko ; Arahata, Yukie ; Sato, Tetsuya ; Hirayama, Yoshimichi ; Hirai, Katsuki ; Yanai, Masaaki ; Nikaido, Kaori ; Maeda, Akihiko ; Torisu, Hiroyuki ; Okada, Kenji ; Sakai, Yasunari ; Ohga, Shoichi. / A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan. :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019 ; 巻 68, 番号 12. pp. 2099-2104.
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abstract = "BACKGROUND: Japanese encephalitis (JE) is the leading cause of viral encephalitis with high mortality and morbidity in Asia. In Japan, however, the active recommendation of JE vaccine was retracted in 2005 because of the potential risk of acute disseminated encephalomyelitis. We aimed to determine the recent incidence of childhood-onset JE after the domestic change of vaccination policy in Japan, and to analyze the clinical features of affected children. METHODS: A retrospective nationwide survey was conducted for pediatric patients with JE in Japan from 1995 to 2015. The national surveillance system was used to identify the pediatric patients with JE. Follow-up questionnaires were sent to analyze their clinical and neuroimaging profiles. RESULTS: Among a total of 109 patients registered to the national surveillance, 10 (9{\%}) were less than age 15 years. The annual incidence rate of childhood-onset JE was higher during 2005-15 than that during 1995-2004 (4.3 × 10-3 vs 1.1 × 10-3 per 100000, respectively; P = .04). Endemic regions overlapped with prefectures that farmed pigs harboring antibodies against JE virus with high prevalence. Detailed clinical data were collected from 9 patients. None of them died, but 5 of 9 patients (56{\%}) had neurological sequelae after recovery. One patient who was partially vaccinated with 2 doses of JE vaccine fully recovered from a coma. The age of 3 years or less was associated with unfavorable neurological prognosis. CONCLUSIONS: Our data provide evidence for the importance and prophylactic effect of the JE vaccine in young children in the endemic area.",
author = "Etsuro Nanishi and Takayuki Hoshina and Masafumi Sanefuji and Ryo Kadoya and Katsuhiko Kitazawa and Yukie Arahata and Tetsuya Sato and Yoshimichi Hirayama and Katsuki Hirai and Masaaki Yanai and Kaori Nikaido and Akihiko Maeda and Hiroyuki Torisu and Kenji Okada and Yasunari Sakai and Shoichi Ohga",
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T1 - A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan

AU - Nanishi, Etsuro

AU - Hoshina, Takayuki

AU - Sanefuji, Masafumi

AU - Kadoya, Ryo

AU - Kitazawa, Katsuhiko

AU - Arahata, Yukie

AU - Sato, Tetsuya

AU - Hirayama, Yoshimichi

AU - Hirai, Katsuki

AU - Yanai, Masaaki

AU - Nikaido, Kaori

AU - Maeda, Akihiko

AU - Torisu, Hiroyuki

AU - Okada, Kenji

AU - Sakai, Yasunari

AU - Ohga, Shoichi

PY - 2019/5/30

Y1 - 2019/5/30

N2 - BACKGROUND: Japanese encephalitis (JE) is the leading cause of viral encephalitis with high mortality and morbidity in Asia. In Japan, however, the active recommendation of JE vaccine was retracted in 2005 because of the potential risk of acute disseminated encephalomyelitis. We aimed to determine the recent incidence of childhood-onset JE after the domestic change of vaccination policy in Japan, and to analyze the clinical features of affected children. METHODS: A retrospective nationwide survey was conducted for pediatric patients with JE in Japan from 1995 to 2015. The national surveillance system was used to identify the pediatric patients with JE. Follow-up questionnaires were sent to analyze their clinical and neuroimaging profiles. RESULTS: Among a total of 109 patients registered to the national surveillance, 10 (9%) were less than age 15 years. The annual incidence rate of childhood-onset JE was higher during 2005-15 than that during 1995-2004 (4.3 × 10-3 vs 1.1 × 10-3 per 100000, respectively; P = .04). Endemic regions overlapped with prefectures that farmed pigs harboring antibodies against JE virus with high prevalence. Detailed clinical data were collected from 9 patients. None of them died, but 5 of 9 patients (56%) had neurological sequelae after recovery. One patient who was partially vaccinated with 2 doses of JE vaccine fully recovered from a coma. The age of 3 years or less was associated with unfavorable neurological prognosis. CONCLUSIONS: Our data provide evidence for the importance and prophylactic effect of the JE vaccine in young children in the endemic area.

AB - BACKGROUND: Japanese encephalitis (JE) is the leading cause of viral encephalitis with high mortality and morbidity in Asia. In Japan, however, the active recommendation of JE vaccine was retracted in 2005 because of the potential risk of acute disseminated encephalomyelitis. We aimed to determine the recent incidence of childhood-onset JE after the domestic change of vaccination policy in Japan, and to analyze the clinical features of affected children. METHODS: A retrospective nationwide survey was conducted for pediatric patients with JE in Japan from 1995 to 2015. The national surveillance system was used to identify the pediatric patients with JE. Follow-up questionnaires were sent to analyze their clinical and neuroimaging profiles. RESULTS: Among a total of 109 patients registered to the national surveillance, 10 (9%) were less than age 15 years. The annual incidence rate of childhood-onset JE was higher during 2005-15 than that during 1995-2004 (4.3 × 10-3 vs 1.1 × 10-3 per 100000, respectively; P = .04). Endemic regions overlapped with prefectures that farmed pigs harboring antibodies against JE virus with high prevalence. Detailed clinical data were collected from 9 patients. None of them died, but 5 of 9 patients (56%) had neurological sequelae after recovery. One patient who was partially vaccinated with 2 doses of JE vaccine fully recovered from a coma. The age of 3 years or less was associated with unfavorable neurological prognosis. CONCLUSIONS: Our data provide evidence for the importance and prophylactic effect of the JE vaccine in young children in the endemic area.

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DO - 10.1093/cid/ciy816

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JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 12

ER -