Combinatorial technologies with the use of a solid-phase pentapeptide library and the magnetic beads covalently bound with the target nonapeptide (1) were applied to search for recognition peptides toward the target sequence (1) which constitutes an extracellular part of the dopamine D2 receptor. Several pentapeptides have been identified to exhibit high binding affinities toward the target peptide (1) in an aqueous solution.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry