A new family of LTR-like sequences abundantly expressed in rat tumors

Noriaki Suzuki, Toshinobu Fujiyoshi, Yoshihiko Maehara, Keikichi Takahashi, Mikio Yamamoto, Hidya Endo

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)


We report the identification of two genome DNA fragments containing middle repetitive sequences abundantly expressed in various rat tumors but rarely in normal tissues. These fragments included homologous regions which belonged to a new family of long terminal repeat (LTR) like sequences, designated RAL elements; one displayed the solitary type and the other a provirus structure. The element was transcribed in a strand specific fashion and started from the presumptive cap site within the RAL element. The presumptive polyA addition site within the element was also utilized as evidence of the analysis of a cDNA clone containing the RAL element. This evidence suggested that transcriptional control signals within the element were functioning. Run on assay revealed that expression of the element was regulated at the transcriptional level.

ジャーナルNucleic acids research
出版ステータス出版済み - 12 9 1986

All Science Journal Classification (ASJC) codes

  • Genetics

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