A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects

Kazuyoshi Tsutsui, E. Saigoh, H. Yin, T. Ubuka, Vishwajit Surchowdhury, T. Osugi, K. Ukena, P. J. Sharp, J. C. Wingfield, G. E. Bentley

研究成果: Contribution to journalArticle

27 引用 (Scopus)

抜粋

In vertebrates, the neuropeptide control of gonadotrophin secretion is primarily through the stimulatory action of the hypothalamic decapeptide, gonadotrophin-releasing hormone (GnRH). Gonadal sex steroids and inhibin inhibit gonadotrophin secretion via feedback from the gonads, but a hypothalamic neuropeptide inhibiting gonadotrophin secretion was, until recently, unknown in vertebrates. In 2000, we discovered a novel hypothalamic dodecapeptide that directly inhibits gonadotrophin release in quail and termed it gonadotrophin-inhibitory hormone (GnIH). GnIH acts on the pituitary and GnRH neurones in the hypothalamus via a novel G-protein-coupled receptor for GnIH to inhibit gonadal development and maintenance by decreasing gonadotrophin release and synthesis. The pineal hormone melatonin is a key factor controlling GnIH neural function. GnIH occurs in the hypothalamus of several avian species and is considered to be a new key neurohormone inhibiting avian reproduction. Thus, the discovery of GnIH provides novel directions to investigate neuropeptide regulation of reproduction. This review summarises the discovery, progress and prospects of GnIH, a new key neurohormone controlling reproduction.

元の言語英語
ページ(範囲)271-275
ページ数5
ジャーナルJournal of Neuroendocrinology
21
発行部数4
DOI
出版物ステータス出版済み - 4 7 2009
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

フィンガープリント A new key neurohormone controlling reproduction, gonadotrophin-inhibitory hormone in birds: Discovery, progress and prospects' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用