A nitric oxide synthase inhibitor attenuates neuropeptide y - and clonidine- induced feeding in the neonatal chick

T. Bungo, Y. H. Choi, M. Shimojo, Y. Masuda, D. M. Denbow, M. Furuse

研究成果: Contribution to journalArticle査読

3 被引用数 (Scopus)

抄録

It is reported that inhibition of nitric oxide (NO) synthase (NOS) decreased food intake in mammalian and avian species. On the other liand, central administration of α3-agonists stimulated. food intake in both species. Similarly, neuropeptide Y (NPY) has the orexigenic effect mediated by α2, receptors. The present study was done to determine whether central injection of NG-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, in the neonatal chick modulates uie increase in food intake induced by NPY- and clonidine (CLON, a. specifie α2-agonist)- induced food intake. Both NPY (2.5 μg)- and CLON (50 ng)-induced food. intake of neona.tal chicks was significantly attenuated by co- administration with the higher doses of L-NAME (0, 0.2, 0.4 and 0.8 mg). Our results suggest that NO may internet with orexigenie systems in modulating food intake in the neonatal chick.

本文言語英語
ページ(範囲)257-264
ページ数8
ジャーナルJournal of Applied Animal Research
17
2
DOI
出版ステータス出版済み - 2000

All Science Journal Classification (ASJC) codes

  • 動物科学および動物学
  • 獣医学(全般)

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