抄録
A highly efficient synthesis of the key intermediate 2 of 1β-methylcarbapenems was accomplished in 10 steps and 30% overall yield starting from commercially available (S)-methyl 3-hydroxy-2-methylpropionate. The explored synthetic scheme features the addition reaction of diketene with a chiral imine as a key diastereoselective step.
本文言語 | 英語 |
---|---|
ページ(範囲) | 6241-6244 |
ページ数 | 4 |
ジャーナル | Tetrahedron Letters |
巻 | 27 |
号 | 51 |
DOI | |
出版ステータス | 出版済み - 1986 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 生化学
- 創薬
- 有機化学