A novel and efficient synthesis of the key intermediate of 1β-methylcarbapenem antibiotics from (s)-methyl 3-hydroxy-2-methylpropionate

Takeo Kawabata; Yoshikazu Kimura; Yoshio Ito; Shiro Terashima; Akira Sasaki; Makoto Sunagawa

doi:10.1016/S0040-4039(00)85442-8

A novel and efficient synthesis of the key intermediate of 1β-methylcarbapenem antibiotics from (s)-methyl 3-hydroxy-2-methylpropionate

Takeo Kawabata, Yoshikazu Kimura, Yoshio Ito, Shiro Terashima, Akira Sasaki, Makoto Sunagawa

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

38 被引用数 (Scopus)

抄録

A highly efficient synthesis of the key intermediate 2 of 1β-methylcarbapenems was accomplished in 10 steps and 30% overall yield starting from commercially available (S)-methyl 3-hydroxy-2-methylpropionate. The explored synthetic scheme features the addition reaction of diketene with a chiral imine as a key diastereoselective step.

本文言語	英語
ページ（範囲）	6241-6244
ページ数	4
ジャーナル	Tetrahedron Letters
巻	27
号	51
DOI	https://doi.org/10.1016/S0040-4039(00)85442-8
出版ステータス	出版済み - 1986
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

文献へのアクセス

10.1016/S0040-4039(00)85442-8

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引用スタイル

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abstract = "A highly efficient synthesis of the key intermediate 2 of 1β-methylcarbapenems was accomplished in 10 steps and 30% overall yield starting from commercially available (S)-methyl 3-hydroxy-2-methylpropionate. The explored synthetic scheme features the addition reaction of diketene with a chiral imine as a key diastereoselective step.",

author = "Takeo Kawabata and Yoshikazu Kimura and Yoshio Ito and Shiro Terashima and Akira Sasaki and Makoto Sunagawa",

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AU - Terashima, Shiro

AU - Sasaki, Akira

AU - Sunagawa, Makoto

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