A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis

Hiroyuki Nishimori, Takayuki Shiratsuchi, Tsutomu Urano, Yasutoshi Kimura, Kunihiko Kiyono, Kunihiko Tatsumi, Shigeo Yoshida, Mayumi Ono, Michihiko Kuwano, Yusuke Nakamura, Takashi Tokino

研究成果: Contribution to journalArticle査読

243 被引用数 (Scopus)

抄録

The genetic alteration of p53 is associated with neovascularization during progression of glioma to its more malignant form, glioblastoma. Hence, one or more of the genes transactivated by p53 is likely to function as an angiogenesis inhibitors. We isolated a novel p53-inducible gene that encodes a 1584-amino-acid product containing five thrombospondin type 1 (TSP-type 1) repeats and is specifically expressed in the brain. A recombinant protein corresponding to the TSP-type 1 repeats of this gene product inhibited in vivo neovascularization induced by bFGF in the rat cornea. The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell lines, suggesting BAI1 plays a significant role in angiogenesis inhibition, as a mediator of p53.

本文言語英語
ページ(範囲)2145-2150
ページ数6
ジャーナルOncogene
15
18
DOI
出版ステータス出版済み - 1997

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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