A novel CD3 J11d+ subset of CD4+CD8 cells repopulating thymus in radiation bone marrow chimeras

Koji Matsumoto, Yasunobu Yoshikai, Goro Matsuzaki, Taiji Asano, Kikuo Nomoto

    研究成果: Contribution to journalArticle査読

    46 被引用数 (Scopus)


    Sequential appearance of T cell subpopulations occurs in the thymus of irradiated AKR (H‐2k, Thy‐1.1) mice at an early stage after transplantation with bone marrow cells of C3H/HeN (H‐2k, Thy‐1.2) mice. The donor‐derived thymocytes were first detected on day 8 after bone marrow reconstitution. Although most of the thymocytes were CD4CD8 cells, an appreciable level of CD4+CD8+ cells was detected in the thymus at this stage. The early appearing CD4+CD8 cells were a novel subset of thymocytes that were J11d+CD3. From day 10 to day 21 the proportion of CD4+CD8CD3J11d+ cells decreased while the proportion of CD4+CD8 cells and CD4+CD8CD3+J11d cells increased. The CD4+CD8CD3 cells seem to diversify to form CD4+CD8+ thymocytes after short‐term culture in vitro. These results suggested the existence of a differential pathway from CD4CD8 cells to CD4+CD8+ cells via CD4+CD8 cells in the thymus.

    ジャーナルEuropean Journal of Immunology
    出版ステータス出版済み - 7 1989

    All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学


    「A novel CD3<sup>‐</sup> J11d<sup>+</sup> subset of CD4<sup>+</sup>CD8<sup>‐</sup> cells repopulating thymus in radiation bone marrow chimeras」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。