A novel G-protein-coupled receptor gene expressed in striatum

Kazuyuki Mizushima, Yasuhide Miyamoto, Fujiko Tsukahara, Momoki Hirai, Yoshiyuki Sakaki, Takashi Ito

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

抄録

Differential display screening for region-specific transcripts in rat brain revealed a novel striatum-specific transcript encoding an orphan G-protein-coupled receptor (GPCR) designated Strg/Gpr88 for striatum-specific GPCR. We isolated its homologues from human (HGMW-approved symbol GPR88) and mouse and mapped them to chromosomes 1p21.3 and 3G1, respectively. These loci are syntenic to each other, thereby suggesting their orthology. The predicted primary sequences of Strg/Gpr88 proteins are highly conserved between human and rodents and show the highest level of homology to receptors for biogenic amines. However, Strg/Gpr88 lacks some residues conserved in all known biogenic amine receptors and hence may represent a novel subtype of GPCR. Northern blot and in situ hybridization analyses revealed that Strg/Gpr88 transcripts are expressed almost exclusively in striatum in both human and rodents. Remarkable conservation in primary structure and a unique expression pattern may indicate a role for Strg/Gpr88 in the fundamental functions of striatum such as the control of motor behavior. (C) 2000 Academic Press.

元の言語英語
ページ(範囲)314-321
ページ数8
ジャーナルGenomics
69
発行部数3
DOI
出版物ステータス出版済み - 11 1 2000

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Biogenic Amines Receptors
G-Protein-Coupled Receptors
Rodentia
Genes
Behavior Control
Northern Blotting
In Situ Hybridization
Chromosomes
Brain
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Mizushima, K., Miyamoto, Y., Tsukahara, F., Hirai, M., Sakaki, Y., & Ito, T. (2000). A novel G-protein-coupled receptor gene expressed in striatum. Genomics, 69(3), 314-321. https://doi.org/10.1006/geno.2000.6340

A novel G-protein-coupled receptor gene expressed in striatum. / Mizushima, Kazuyuki; Miyamoto, Yasuhide; Tsukahara, Fujiko; Hirai, Momoki; Sakaki, Yoshiyuki; Ito, Takashi.

:: Genomics, 巻 69, 番号 3, 01.11.2000, p. 314-321.

研究成果: ジャーナルへの寄稿記事

Mizushima, K, Miyamoto, Y, Tsukahara, F, Hirai, M, Sakaki, Y & Ito, T 2000, 'A novel G-protein-coupled receptor gene expressed in striatum', Genomics, 巻. 69, 番号 3, pp. 314-321. https://doi.org/10.1006/geno.2000.6340
Mizushima K, Miyamoto Y, Tsukahara F, Hirai M, Sakaki Y, Ito T. A novel G-protein-coupled receptor gene expressed in striatum. Genomics. 2000 11 1;69(3):314-321. https://doi.org/10.1006/geno.2000.6340
Mizushima, Kazuyuki ; Miyamoto, Yasuhide ; Tsukahara, Fujiko ; Hirai, Momoki ; Sakaki, Yoshiyuki ; Ito, Takashi. / A novel G-protein-coupled receptor gene expressed in striatum. :: Genomics. 2000 ; 巻 69, 番号 3. pp. 314-321.
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