A novel gene carrier for the therapy of viral infection disease

Masanori Kuramoto, Kenji Kawamura, Daisuke Asai, Takeshi Mori, Takurou Niidome, Yoko Shoji, Hideki Nakashima, Yoshiki Katayama

研究成果: 会議への寄与タイプ論文

抄録

We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

元の言語英語
ページ数1
出版物ステータス出版済み - 12 1 2006
イベント55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, 日本
継続期間: 9 20 20069 22 2006

その他

その他55th Society of Polymer Science Japan Symposium on Macromolecules
日本
Toyama
期間9/20/069/22/06

Fingerprint

Peptides
Genes
DNA
Viruses
Polymers
Substrates
Peptide Hydrolases

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Kuramoto, M., Kawamura, K., Asai, D., Mori, T., Niidome, T., Shoji, Y., ... Katayama, Y. (2006). A novel gene carrier for the therapy of viral infection disease. 論文発表場所 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本.

A novel gene carrier for the therapy of viral infection disease. / Kuramoto, Masanori; Kawamura, Kenji; Asai, Daisuke; Mori, Takeshi; Niidome, Takurou; Shoji, Yoko; Nakashima, Hideki; Katayama, Yoshiki.

2006. 論文発表場所 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本.

研究成果: 会議への寄与タイプ論文

Kuramoto, M, Kawamura, K, Asai, D, Mori, T, Niidome, T, Shoji, Y, Nakashima, H & Katayama, Y 2006, 'A novel gene carrier for the therapy of viral infection disease', 論文発表場所 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本, 9/20/06 - 9/22/06.
Kuramoto M, Kawamura K, Asai D, Mori T, Niidome T, Shoji Y その他. A novel gene carrier for the therapy of viral infection disease. 2006. 論文発表場所 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本.
Kuramoto, Masanori ; Kawamura, Kenji ; Asai, Daisuke ; Mori, Takeshi ; Niidome, Takurou ; Shoji, Yoko ; Nakashima, Hideki ; Katayama, Yoshiki. / A novel gene carrier for the therapy of viral infection disease. 論文発表場所 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, 日本.1 p.
@conference{4043182d59214622a0f7506244aab0c4,
title = "A novel gene carrier for the therapy of viral infection disease",
abstract = "We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.",
author = "Masanori Kuramoto and Kenji Kawamura and Daisuke Asai and Takeshi Mori and Takurou Niidome and Yoko Shoji and Hideki Nakashima and Yoshiki Katayama",
year = "2006",
month = "12",
day = "1",
language = "English",
note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

}

TY - CONF

T1 - A novel gene carrier for the therapy of viral infection disease

AU - Kuramoto, Masanori

AU - Kawamura, Kenji

AU - Asai, Daisuke

AU - Mori, Takeshi

AU - Niidome, Takurou

AU - Shoji, Yoko

AU - Nakashima, Hideki

AU - Katayama, Yoshiki

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

AB - We designed a polymer-peptide conjugate as a gene carrier, which consists of uncharged main chain and cationic peptide side chain. This peptide side chain contained the substrate peptide sequence for HIV-I protease and cationic peptide sequence. This cationic carrier interacted with anionic DNA, leading to polyion-complex. On the other hand, this carrier released the DNA from the complex due to the cleavage of cationic portion from the peptide side chain by virus protease. In this report, we assayed function of this carrier in cell free system.

UR - http://www.scopus.com/inward/record.url?scp=33846144803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846144803&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846144803

ER -