A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation

Kunihito Gotoh, Terumasa Yamada, Osamu Ishikawa, Hidenori Takahashi, Hidetoshi Eguchi, Masahiko Yano, Hiroaki Ohigashi, Yasuhiko Tomita, Yasuhide Miyamoto, Shingi Imaoka

研究成果: Contribution to journalArticle査読

228 被引用数 (Scopus)

抄録

Background and Objectives: The clear delineation between tumor and normal tissue is ideal for real-time surgical navigation imaging. We present a novel indocyanine green (ICG) fluorescence imaging technique to visualize hepatocellular carcinoma (HCC). Methods: Ten patients with solitary HCC underwent hepatectomy between February and September 2007 at Osaka Medical Center for Cancer and Cardiovascular Diseases. ICG had been injected intravenously several days before surgery at a dose of 0.5 mg/kg body weight. After laparotomy, the liver was inspected with intraoperative ultrasonography (IOUS), and then with a near-infrared (NIR) fluorescence imaging system (PDE; Hamamatsu Photonics K.K. Hamamatsu, Japan). Results: All the 10 primary tumors showed bright fluorescent signals and could be completely removed with negative margins under the guide of PDE. In four cases (40.0%), new HCC nodules that were not detected by use of any preoperative examinations including IOUS were detected by PDE. These newly identified HCC nodules were very small in size and most of the tumors were well-differentiated HCCs. Conclusions: This novel technique is simple and safe, and is therefore considered to be a promising tool for routine intraoperative imaging during a hepatic resection and further clinical exploration for HCC.

本文言語英語
ページ(範囲)75-79
ページ数5
ジャーナルJournal of Surgical Oncology
100
1
DOI
出版ステータス出版済み - 7 1 2009

All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学

フィンガープリント

「A novel image-guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル