A novel metabolic communication between neurons and astrocytes: Non-essential amino acid L-serine released from astrocytes is essential for developing hippocampal neurons

Junya Mitoma, Shigeki Furuya, Yoshio Hirabayashi

研究成果: Contribution to journalArticle査読

76 被引用数 (Scopus)

抄録

A hippocampal astrocyte conditioned medium (HACM) supported the survival of hippocampal neurons under a serum-, glia-free culture setting. The neurotrophic activity in HACM was mostly recovered in low molecular weight fractions (M(r) < 3000), which contained high levels of L-serine and L-alanine. However, L-serine alone significantly improved the neuronal survival and neurite growth in a stereo-specific manner. Other non-essential amino acids had no effect. These results strongly suggest that L-serine, released by astrocytes, is essential for the survival and phenotypic growth of hippocampal neurons.

本文言語英語
ページ(範囲)195-199
ページ数5
ジャーナルNeuroscience Research
30
2
DOI
出版ステータス出版済み - 1 1 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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