A novel method of preparing amine-modifying C-4' oxidized nucleotide

Mariko Aso, K. Ryuo, M. Kondo, H. Suemune

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

A novel method of preparing C-4' oxidized nucleotide, a monomeric model of an alkali labile lesion (1) has been studied. The C-4' selenated 4a and 4b were found to be effective in preparing 3, a monomeric model of 1, by the reaction with NBS (N-bromosuccinimide). The successive reaction of 3 with amine at room temperature afforded the α,β-unsaturated γ-methylene-γ-lactam (2) in good yield.

元の言語英語
ページ(範囲)1384-1386
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
48
発行部数9
DOI
出版物ステータス出版済み - 1 1 2000

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Bromosuccinimide
Lactams
Alkalies
Amines
Nucleotides
Temperature

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

これを引用

A novel method of preparing amine-modifying C-4' oxidized nucleotide. / Aso, Mariko; Ryuo, K.; Kondo, M.; Suemune, H.

:: Chemical and Pharmaceutical Bulletin, 巻 48, 番号 9, 01.01.2000, p. 1384-1386.

研究成果: ジャーナルへの寄稿記事

Aso, Mariko ; Ryuo, K. ; Kondo, M. ; Suemune, H. / A novel method of preparing amine-modifying C-4' oxidized nucleotide. :: Chemical and Pharmaceutical Bulletin. 2000 ; 巻 48, 番号 9. pp. 1384-1386.
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