A Novel Monoclonal Antibody disrupting Cell Type Specific Substratum Adhesion of Frog (Xenopus laevis) Epithelial Cells and Endothelial Cells: (frog, Xenopus laevis/cell substratum adhesion/cell adhesion/endothelial cells)

Kazuya Nomura, Tatsuya Tajima, Hajime Nomura, Kiyomi Tsuno, Yasuo Fujimura, Nobushige Nakajo, Kiyotaka Yamana

研究成果: ジャーナルへの寄稿学術誌査読

抄録

We isolated a mouse monoclonal antibody (FAD‐II) that disrupts cell‐substratum adhesion of amphibian (Xenopus laevis) epithelial cells and endothelial cells. The effect of the antibody was cell‐type specific, and the antibody had no effect on fibroblastic cells while fibronectin peptide blocked cell‐substratum adhesion of all the cell types examined. In developing frog embryos, the epitopes recognized by the antibody were detected in pronephrotic ducts and in other tissue cells of embryos (from stage 33/34 afterwards). In adult tissues, the antibody mainly recognized antigens in extracelluar matrices. The antigens recognized by the antibody seems to be novel glycoepitopes in frog cells.

本文言語英語
ページ(範囲)639-649
ページ数11
ジャーナルDevelopment, Growth & Differentiation
33
6
DOI
出版ステータス出版済み - 1月 1 1991

!!!All Science Journal Classification (ASJC) codes

  • 発生生物学
  • 細胞生物学

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