A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia

Jun-Ichi Kira, Takashi Inuzuka, Isao Hozumi, Hajime Wada, Kaoru Tanaka, Hisashi Gondo, Shuzo Sato, Shoji Tsuji, Takuro Kobayashi

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

We report on the case of a 70-year-old man with primary macroglobulinemia who showed cranial polyneuropathy and extensive radiculoneuropathy. His serum contained an IgM λ monoclonal antibody which reacted with both a high molecular weight protein in grey matter and purified myelin basic protein (MBP) on immunoblotting. In an immunohistochemical study, strong immunoreactivity was detected only in the cytoplasm of neurons and weak immunoreactivity was detected in myelin. These findings suggest that this antibody may be related to the pathogenesis of neuronal damage in patients with macroglobulinemia.

元の言語英語
ページ(範囲)47-52
ページ数6
ジャーナルJournal of the Neurological Sciences
148
発行部数1
DOI
出版物ステータス出版済み - 5 1 1997

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Waldenstrom Macroglobulinemia
Myelin Basic Protein
Molecular Weight
Monoclonal Antibodies
Polyneuropathies
Myelin Sheath
Immunoblotting
Immunoglobulin M
Cytoplasm
Proteins
Neurons
Antibodies
Serum
Gray Matter

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. / Kira, Jun-Ichi; Inuzuka, Takashi; Hozumi, Isao; Wada, Hajime; Tanaka, Kaoru; Gondo, Hisashi; Sato, Shuzo; Tsuji, Shoji; Kobayashi, Takuro.

:: Journal of the Neurological Sciences, 巻 148, 番号 1, 01.05.1997, p. 47-52.

研究成果: ジャーナルへの寄稿記事

Kira, Jun-Ichi ; Inuzuka, Takashi ; Hozumi, Isao ; Wada, Hajime ; Tanaka, Kaoru ; Gondo, Hisashi ; Sato, Shuzo ; Tsuji, Shoji ; Kobayashi, Takuro. / A novel monoclonal antibody which reacts with a high molecular weight neuronal cytoplasmic protein and myelin basic protein (MBP) in a patient with macroglobulinemia. :: Journal of the Neurological Sciences. 1997 ; 巻 148, 番号 1. pp. 47-52.
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AU - Wada, Hajime

AU - Tanaka, Kaoru

AU - Gondo, Hisashi

AU - Sato, Shuzo

AU - Tsuji, Shoji

AU - Kobayashi, Takuro

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