A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease

Atsuyo Ikeda, Norikatsu Miyoshi, Shiki Fujino, Hideki Iijima, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Chu Matsuda, Yuichiro Doki, Masaki Mori, Tsunekazu Mizushima

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

抄録

Background/Aims: Endoscopic recurrence (ER) after intestinal resection for Crohn's disease (CD) precedes the clinical recurrence, and the severity of ER correlates with the severity of the subsequent clinical recurrence. This study aimed to identify risk factors related to early ER after intestinal resection for CD and to create a prediction model. Methods: The patients who underwent intestinal resection for CD between April 2008 and April 2017 and took endoscopic evaluation between 6 and 12 months after surgery were retrospectively analyzed. Results: A total of 15 out of 52 (29%) patients developed early ER. A univariate analysis demonstrated that early ER was significantly correlated with history of prior intestinal resections for CD (p = 0.005), low preoperative albumin levels (p = 0.035), and excessive perioperative inflammation (i.e., high C-reactive protein levels in both preoperative and postoperative periods; p = 0.034). Based on these clinical factors, a nomogram for predicting early ER was created with the area under the curve 0.808. Conclusion: We developed a novel predictive nomogram for early ER after intestinal resection for CD. This prediction model might assist clinicians in managing patients with CD after an intestinal resection. Additional validation studies are currently being developed.

元の言語英語
ページ(範囲)269-276
ページ数8
ジャーナルDigestion
100
発行部数4
DOI
出版物ステータス出版済み - 11 1 2019

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Nomograms
Crohn Disease
Recurrence
Preoperative Period
Validation Studies
Postoperative Period
C-Reactive Protein
Area Under Curve
Albumins
Inflammation

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Ikeda, A., Miyoshi, N., Fujino, S., Iijima, H., Takahashi, H., Haraguchi, N., ... Mizushima, T. (2019). A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease. Digestion, 100(4), 269-276. https://doi.org/10.1159/000495981

A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease. / Ikeda, Atsuyo; Miyoshi, Norikatsu; Fujino, Shiki; Iijima, Hideki; Takahashi, Hidekazu; Haraguchi, Naotsugu; Nishimura, Junichi; Hata, Taishi; Matsuda, Chu; Doki, Yuichiro; Mori, Masaki; Mizushima, Tsunekazu.

:: Digestion, 巻 100, 番号 4, 01.11.2019, p. 269-276.

研究成果: ジャーナルへの寄稿コメント/討論

Ikeda, A, Miyoshi, N, Fujino, S, Iijima, H, Takahashi, H, Haraguchi, N, Nishimura, J, Hata, T, Matsuda, C, Doki, Y, Mori, M & Mizushima, T 2019, 'A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease', Digestion, 巻. 100, 番号 4, pp. 269-276. https://doi.org/10.1159/000495981
Ikeda A, Miyoshi N, Fujino S, Iijima H, Takahashi H, Haraguchi N その他. A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease. Digestion. 2019 11 1;100(4):269-276. https://doi.org/10.1159/000495981
Ikeda, Atsuyo ; Miyoshi, Norikatsu ; Fujino, Shiki ; Iijima, Hideki ; Takahashi, Hidekazu ; Haraguchi, Naotsugu ; Nishimura, Junichi ; Hata, Taishi ; Matsuda, Chu ; Doki, Yuichiro ; Mori, Masaki ; Mizushima, Tsunekazu. / A Novel Predictive Nomogram for Early Endoscopic Recurrence after Intestinal Resection for Crohn's Disease. :: Digestion. 2019 ; 巻 100, 番号 4. pp. 269-276.
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author = "Atsuyo Ikeda and Norikatsu Miyoshi and Shiki Fujino and Hideki Iijima and Hidekazu Takahashi and Naotsugu Haraguchi and Junichi Nishimura and Taishi Hata and Chu Matsuda and Yuichiro Doki and Masaki Mori and Tsunekazu Mizushima",
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AU - Ikeda, Atsuyo

AU - Miyoshi, Norikatsu

AU - Fujino, Shiki

AU - Iijima, Hideki

AU - Takahashi, Hidekazu

AU - Haraguchi, Naotsugu

AU - Nishimura, Junichi

AU - Hata, Taishi

AU - Matsuda, Chu

AU - Doki, Yuichiro

AU - Mori, Masaki

AU - Mizushima, Tsunekazu

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N2 - Background/Aims: Endoscopic recurrence (ER) after intestinal resection for Crohn's disease (CD) precedes the clinical recurrence, and the severity of ER correlates with the severity of the subsequent clinical recurrence. This study aimed to identify risk factors related to early ER after intestinal resection for CD and to create a prediction model. Methods: The patients who underwent intestinal resection for CD between April 2008 and April 2017 and took endoscopic evaluation between 6 and 12 months after surgery were retrospectively analyzed. Results: A total of 15 out of 52 (29%) patients developed early ER. A univariate analysis demonstrated that early ER was significantly correlated with history of prior intestinal resections for CD (p = 0.005), low preoperative albumin levels (p = 0.035), and excessive perioperative inflammation (i.e., high C-reactive protein levels in both preoperative and postoperative periods; p = 0.034). Based on these clinical factors, a nomogram for predicting early ER was created with the area under the curve 0.808. Conclusion: We developed a novel predictive nomogram for early ER after intestinal resection for CD. This prediction model might assist clinicians in managing patients with CD after an intestinal resection. Additional validation studies are currently being developed.

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