A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells

Hitoshi Nishimura, Toshiki Yajima, Hiromi Muta, Eckhard R. Podack, Kenzaburo Tani, Yasunobu Yoshikai

    研究成果: Contribution to journalArticle査読

    36 被引用数 (Scopus)

    抄録

    Memory CD8+ T cells can be divided into two subsets, central memory (TCM) and effector memory (TEM) CD8+ T cells. We foend that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR seperfamily, signaling is involved in differentiation of long-lived CD8+ TCM cells following Listeria monocytogenes infection. Although CD8+ TEM cells transiently accumulated in the noalymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ TCM cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ TEM cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for TCM cells.

    本文言語英語
    ページ(範囲)4627-4634
    ページ数8
    ジャーナルJournal of Immunology
    175
    7
    DOI
    出版ステータス出版済み - 10 1 2005

    All Science Journal Classification (ASJC) codes

    • 免疫アレルギー学
    • 免疫学

    フィンガープリント

    「A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8<sup>+</sup> T cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル