A novel synthesis of the 1β-methylcarbapenem key intermediate employing the [2+2]-cycloaddition reaction of chlorosulfonyl isocyanate with a 4H-1,3-dioxin derivative

Yoshio Ito, Yuko Kobayashi, Shiro Terashima

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

A highly stereoselective synthetic route to the title compound was explored by featuring the [2+2]-cycloaddition reaction of chlorosulfonyl isocyanate with the 4H-1,3-dioxin derivative readily obtainable from methyl (R)-3-hydroxybutyrate, the Baeyer-Villiger reaction resulting in novel cleavage of the acetal moiety, and the Reformatsky reaction with sterically crowded 3-(2-bromopropionyl)-2-oxazolidone derivatives.

本文言語英語
ページ(範囲)5631-5634
ページ数4
ジャーナルTetrahedron Letters
30
41
DOI
出版ステータス出版済み - 1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 有機化学
  • 創薬

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