A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite

Inga Grigoraviciute-Puroniene, Yuhei Tanaka, Visata Vegelyte, Yuko Nishimoto, Kunio Ishikawa, Aivaras Kareiva

研究成果: ジャーナルへの寄稿記事

抄録

Synthetic calcium deficient hydroxyapatite (CDHA, with the formula Ca9(HPO4)(PO4)5OH) is a promising material which could be potentially used in biomedicine. The aim of this study was to develop a simple and cost-effective synthesis route for the preparation of low crystalline CDHA granules. A method based on an incessant dissolution-precipitation reaction eventually resulting in a solid and shaped material consisting of the desired phase was utilized. The calcium sulphate hemihydrate was selected as the starting material. The synthesis products obtained were characterized by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). The monophasic calcium deficient hydroxyapatite granules of about 300–350 μm in diameter were synthesized by three slightly different preparative approaches at 70 °C temperature and compared. Independently of the composition of the raw granules synthesized ones were composed of low crystalline an apatitic phase. The granules were calcium deficient as contained HPO4 2− group in their structure. It was demonstrated that the addition of (NH4)H2PO4 or (NH4)2HPO4 into the raw granules could promote the growth of the CDHA crystallites. SEM revealed that the microstructure of synthesized materials was influenced by the chemical composition of the raw granules. Chemical composition and presence of no an X-ray amorphous phase in obtained samples was confirmed by reheating the obtained granules at 800 °C to get monophasic β-TCP. Our work provides a novel and simple approach to produce CDHA granules for various applications.

元の言語英語
ページ(範囲)15620-15623
ページ数4
ジャーナルCeramics International
45
発行部数12
DOI
出版物ステータス出版済み - 8 15 2019

Fingerprint

Durapatite
Hydroxyapatite
Calcium
Chemical analysis
Crystalline materials
Calcium Sulfate
Scanning electron microscopy
Crystallites
X ray diffraction analysis
Infrared spectroscopy
Dissolution
X rays
Microstructure
Costs
Temperature

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry

これを引用

Grigoraviciute-Puroniene, I., Tanaka, Y., Vegelyte, V., Nishimoto, Y., Ishikawa, K., & Kareiva, A. (2019). A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite. Ceramics International, 45(12), 15620-15623. https://doi.org/10.1016/j.ceramint.2019.05.072

A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite. / Grigoraviciute-Puroniene, Inga; Tanaka, Yuhei; Vegelyte, Visata; Nishimoto, Yuko; Ishikawa, Kunio; Kareiva, Aivaras.

:: Ceramics International, 巻 45, 番号 12, 15.08.2019, p. 15620-15623.

研究成果: ジャーナルへの寄稿記事

Grigoraviciute-Puroniene, I, Tanaka, Y, Vegelyte, V, Nishimoto, Y, Ishikawa, K & Kareiva, A 2019, 'A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite', Ceramics International, 巻. 45, 番号 12, pp. 15620-15623. https://doi.org/10.1016/j.ceramint.2019.05.072
Grigoraviciute-Puroniene I, Tanaka Y, Vegelyte V, Nishimoto Y, Ishikawa K, Kareiva A. A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite. Ceramics International. 2019 8 15;45(12):15620-15623. https://doi.org/10.1016/j.ceramint.2019.05.072
Grigoraviciute-Puroniene, Inga ; Tanaka, Yuhei ; Vegelyte, Visata ; Nishimoto, Yuko ; Ishikawa, Kunio ; Kareiva, Aivaras. / A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite. :: Ceramics International. 2019 ; 巻 45, 番号 12. pp. 15620-15623.
@article{20f037282d66493daa110b429d669ad8,
title = "A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite",
abstract = "Synthetic calcium deficient hydroxyapatite (CDHA, with the formula Ca9(HPO4)(PO4)5OH) is a promising material which could be potentially used in biomedicine. The aim of this study was to develop a simple and cost-effective synthesis route for the preparation of low crystalline CDHA granules. A method based on an incessant dissolution-precipitation reaction eventually resulting in a solid and shaped material consisting of the desired phase was utilized. The calcium sulphate hemihydrate was selected as the starting material. The synthesis products obtained were characterized by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). The monophasic calcium deficient hydroxyapatite granules of about 300–350 μm in diameter were synthesized by three slightly different preparative approaches at 70 °C temperature and compared. Independently of the composition of the raw granules synthesized ones were composed of low crystalline an apatitic phase. The granules were calcium deficient as contained HPO4 2− group in their structure. It was demonstrated that the addition of (NH4)H2PO4 or (NH4)2HPO4 into the raw granules could promote the growth of the CDHA crystallites. SEM revealed that the microstructure of synthesized materials was influenced by the chemical composition of the raw granules. Chemical composition and presence of no an X-ray amorphous phase in obtained samples was confirmed by reheating the obtained granules at 800 °C to get monophasic β-TCP. Our work provides a novel and simple approach to produce CDHA granules for various applications.",
author = "Inga Grigoraviciute-Puroniene and Yuhei Tanaka and Visata Vegelyte and Yuko Nishimoto and Kunio Ishikawa and Aivaras Kareiva",
year = "2019",
month = "8",
day = "15",
doi = "10.1016/j.ceramint.2019.05.072",
language = "English",
volume = "45",
pages = "15620--15623",
journal = "Ceramics International",
issn = "0272-8842",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - A novel synthetic approach to low-crystallinity calcium deficient hydroxyapatite

AU - Grigoraviciute-Puroniene, Inga

AU - Tanaka, Yuhei

AU - Vegelyte, Visata

AU - Nishimoto, Yuko

AU - Ishikawa, Kunio

AU - Kareiva, Aivaras

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Synthetic calcium deficient hydroxyapatite (CDHA, with the formula Ca9(HPO4)(PO4)5OH) is a promising material which could be potentially used in biomedicine. The aim of this study was to develop a simple and cost-effective synthesis route for the preparation of low crystalline CDHA granules. A method based on an incessant dissolution-precipitation reaction eventually resulting in a solid and shaped material consisting of the desired phase was utilized. The calcium sulphate hemihydrate was selected as the starting material. The synthesis products obtained were characterized by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). The monophasic calcium deficient hydroxyapatite granules of about 300–350 μm in diameter were synthesized by three slightly different preparative approaches at 70 °C temperature and compared. Independently of the composition of the raw granules synthesized ones were composed of low crystalline an apatitic phase. The granules were calcium deficient as contained HPO4 2− group in their structure. It was demonstrated that the addition of (NH4)H2PO4 or (NH4)2HPO4 into the raw granules could promote the growth of the CDHA crystallites. SEM revealed that the microstructure of synthesized materials was influenced by the chemical composition of the raw granules. Chemical composition and presence of no an X-ray amorphous phase in obtained samples was confirmed by reheating the obtained granules at 800 °C to get monophasic β-TCP. Our work provides a novel and simple approach to produce CDHA granules for various applications.

AB - Synthetic calcium deficient hydroxyapatite (CDHA, with the formula Ca9(HPO4)(PO4)5OH) is a promising material which could be potentially used in biomedicine. The aim of this study was to develop a simple and cost-effective synthesis route for the preparation of low crystalline CDHA granules. A method based on an incessant dissolution-precipitation reaction eventually resulting in a solid and shaped material consisting of the desired phase was utilized. The calcium sulphate hemihydrate was selected as the starting material. The synthesis products obtained were characterized by Fourier transformed infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). The monophasic calcium deficient hydroxyapatite granules of about 300–350 μm in diameter were synthesized by three slightly different preparative approaches at 70 °C temperature and compared. Independently of the composition of the raw granules synthesized ones were composed of low crystalline an apatitic phase. The granules were calcium deficient as contained HPO4 2− group in their structure. It was demonstrated that the addition of (NH4)H2PO4 or (NH4)2HPO4 into the raw granules could promote the growth of the CDHA crystallites. SEM revealed that the microstructure of synthesized materials was influenced by the chemical composition of the raw granules. Chemical composition and presence of no an X-ray amorphous phase in obtained samples was confirmed by reheating the obtained granules at 800 °C to get monophasic β-TCP. Our work provides a novel and simple approach to produce CDHA granules for various applications.

UR - http://www.scopus.com/inward/record.url?scp=85065412383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065412383&partnerID=8YFLogxK

U2 - 10.1016/j.ceramint.2019.05.072

DO - 10.1016/j.ceramint.2019.05.072

M3 - Article

AN - SCOPUS:85065412383

VL - 45

SP - 15620

EP - 15623

JO - Ceramics International

JF - Ceramics International

SN - 0272-8842

IS - 12

ER -