A pancreaticoduodenectomy risk model derived from 8575 cases from a national single-race population (japanese) using a web-based data entry system: The 30-day and in-hospital mortality rates for pancreaticoduodenectomy

Wataru Kimura, Hiroaki Miyata, Mitsukazu Gotoh, Ichiro Hirai, Akira Kenjo, Yuko Kitagawa, Mitsuo Shimada, Hideo Baba, Naohiro Tomita, Tohru Nakagoe, Kenichi Sugihara, Masaki Mori

研究成果: Contribution to journalArticle査読

183 被引用数 (Scopus)

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OBJECTIVE:: To create a mortality risk model after pancreaticoduodenectomy (PD) using a Web-based national database system. BACKGROUND:: PD is a major gastroenterological surgery with relatively high mortality. Many studies have reported factors to analyze short-term outcomes. SUBJECTS AND METHODS:: After initiation of National Clinical Database, approximately 1.2 million surgical cases from more than 3500 Japanese hospitals were collected through a Web-based data entry system. After data cleanup, 8575 PD patients (mean age, 68.2 years) recorded in 2011 from 1167 hospitals were analyzed using variables and definitions almost identical to those of American College of Surgeons-National Surgical Quality Improvement Program. RESULTS:: The 30-day postoperative and in-hospital mortality rates were 1.2% and 2.8% (103 and 239 patients), respectively. Thirteen significant risk factors for in-hospital mortality were identified: age, respiratory distress, activities of daily living within 30 days before surgery, angina, weight loss of more than 10%, American Society of Anesthesiologists class of greater than 3, Brinkman index of more than 400, body mass index of more than 25 kg/m, white blood cell count of more than 11,000 cells per microliter, platelet count of less than 120,000 per microliter, prothrombin time/international normalized ratio of more than 1.1, activated partial thromboplastin time of more than 40 seconds, and serum creatinine levels of more than 3.0 mg/dL. Five variables, including male sex, emergency surgery, chronic obstructive pulmonary disease, bleeding disorders, and serum urea nitrogen levels of less than 8.0 mg/dL, were independent variables in the 30-day mortality group. The overall PD complication rate was 40.0%. Grade B and C pancreatic fistulas in the International Study Group on Pancreatic Fistula occurred in 13.2% cases. The 30-day and in-hospital mortality rates for pancreatic cancer were significantly lower than those for nonpancreatic cancer. CONCLUSIONS:: We conducted the reported risk stratification study for PD using a nationwide surgical database. PD outcomes in the national population were satisfactory, and the risk model could help improve surgical practice quality.

本文言語英語
ページ(範囲)773-780
ページ数8
ジャーナルAnnals of surgery
259
4
DOI
出版ステータス出版済み - 4 2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • Surgery

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