A patient with primary human immunodeficiency virus infection for whom highly active antiretroviral therapy was successful

Norihiro Furusyo, Iwao Ariyama, Yong Chong, Masao Harada, Shigeki Nabeshima, Arahito Mitsutake, Seizaburo Kashiwagi, Jun Hayashi

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

We report the case of a 25-year-old male Japanese homosexual with primary human immunodeficier virus (HIV)-1 infection and early stage syphilis. Approximately 60 days after HIV exposure by sex with another man, the patient abruptly had high fever, after which he experienced a variety of severe, prolonged symptoms such as painful oral mucosa ulcerations, rash, lymphadenopathy, splenomegaly, and a 5.5-kg weight loss. Serum lactate dehydrogenase and liver biochemical test values were elevated. Antibodies to HIV by both enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) test were negative at the time of symptom onset, but serum HIV-1 RNA level was 1585000 copies/ml. Antibody seroconversions were found on day 9 after the onset of symptoms by ELISA and on day 16 by WB test, suggesting primary HIV infection. Within 2 weeks of starting highly active antiretroviral therapy (HAART), all symptoms except lymphadenopathy were resolved, and the serum HIV-1 RNA level dramatically decreased to 5011 copies/ml, eventually becoming undetectable by the standard method. The patient has remained asymptomatic for the 18 months since symptom resolution after HAART, and HIV-1 RNA remains undetectable.

本文言語英語
ページ(範囲)361-364
ページ数4
ジャーナルJournal of Infection and Chemotherapy
8
4
DOI
出版ステータス出版済み - 12 2002

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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