A polymer micelle responding to the protein kinase a signal

Y. Katayama, T. Sonoda, M. Maeda

    研究成果: Contribution to journalArticle査読

    76 被引用数 (Scopus)

    抄録

    New polymer-peptide conjugates, NIPAM-PEP and NIPAM-PEPEP, were designed and synthesized. These graft-type polymers contained a substrate peptide of protein kinase A (PKA), which forms one of the most important intracellular signals in cellular signal transduction. The NIPAM-PEP containing the N-isopropylacrylamide unit and the substrate peptide unit raised its lower critical solution temperature (LCST) from 36.7 to 40 °C in response to phosphorylation by activated PKA. The NIPAM-PEPEP containing another poly(ethylene glycol) unit formed a polymer micelle-type particle above LCST. This particle disintegrated in response to phosphorylation by activated PKA. Dansylaniline, which was encapsulated in the hydrophobic core of the particle, tended to be released with the particle disintegration occurring in response to the PKA signal. NIPAM-PEPEP, which is the first example of a polymer-peptide conjugate responding to an intracellular signal, offers the possibility of a novel, intelligent drug capsule communicating with cells to release its pharmacological activity.

    本文言語英語
    ページ(範囲)8569-8573
    ページ数5
    ジャーナルMacromolecules
    34
    24
    DOI
    出版ステータス出版済み - 11 20 2001

    All Science Journal Classification (ASJC) codes

    • 有機化学
    • ポリマーおよびプラスチック
    • 無機化学
    • 材料化学

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