A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: The J-MICC Study

Sakurako Katsuura-Kamano, Hirokazu Uemura, Kokichi Arisawa, Miwa Yamaguchi, Nobuyuki Hamajima, Kenji Wakai, Rieko Okada, Sadao Suzuki, Naoto Taguchi, Yoshikuni Kita, Keizo Ohnaka, Tara Sefanya Kairupan, Daisuke Matsui, Isao Oze, Haruo Mikami, Michiaki Kubo, Hideo Tanaka

研究成果: Contribution to journalArticle査読

12 被引用数 (Scopus)

抄録

Previously reported associations of a common polymorphism near melanocortin-4 receptor (MC4R) gene (rs17782313) with BMI/obesity were inconsistent, especially in East Asia, and the associations of the polymorphism with serum lipid levels have not been fully elucidated. This study evaluated the association between rs17782313 and obesity-related traits and serum lipid levels in the general Japanese population. A total of 2,035 subjects (aged 35-69 years, 1,024 males and 1,011 females) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We examined the associations between near MC4R polymorphism (rs17782313) and obesity-related traits [height, weight, body mass index (BMI), weight change from 20 years old], serum lipid levels (triglycerides, total and HDL-cholesterol), and intake of nutrients (total energy and macronutrients). Polymorphism of rs17782313 (minor C allele) was positively associated with serum triglyceride levels (P for trend = 0.020) adjusted for age and sex. Analysis using a general linear model revealed that the number of minor C alleles was positively associated with serum triglyceride levels after adjustment for age, sex, and potential confounders (P for trend = 0.004). Statistical significance did not change after further adjustment for total energy intake and BMI. There was no significant association between rs17782313 and obesity-related traits including BMI. Interactions between rs17782313 and sex, BMI, or total energy intake for triglyceride levels were not significant. To our knowledge, this study demonstrated for the first time that rs17782313 was associated with serum triglyceride levels in Asian population. Further studies are needed to confirm this result.

本文言語英語
ページ(範囲)81-89
ページ数9
ジャーナルEndocrine
47
1
DOI
出版ステータス出版済み - 9 2014

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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