A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase

Toyoshi Inoguchi, H. Tsubouchi, T. Etoh, M. Kakimoto, T. Sonta, H. Utsumi, H. Sumimoto, H. Y. Yu, N. Sonoda, M. Inuo, N. Sato, N. Sekiguchi, K. Kobayashi, H. Nawata

研究成果: Contribution to journalReview article査読

36 被引用数 (Scopus)

抄録

A growing body of evidence has shown that oxidative stress may be involved in the development of vascular complications associated with diabetes. However, the molecular mechanism for increased reactive oxygen species (ROS) production in diabetes remains uncertain. Among various possible mechanisms, attention have increasingly been paid to NAD(P)H oxidase as the most important source of ROS production in vascular cells. High glucose level stimulates ROS production through protein kinase C (PKC)-dependent activation of vascular NAD(P)H oxidase. Furthermore, the expression of NAD(P)H oxidase components is increased in micro- and macrovascular tissues of diabetic animals in association with various functional disorders and histochemical abnormalities. These results suggest that vascular NAD(P)H oxidase-driven ROS production may contribute to the onset or development of diabetic micro- or macrovascular complications. In this point of view, the possible new strategy of antioxidative therapy for diabetic vascular complications is discussed in this review.

本文言語英語
ページ(範囲)1759-1764
ページ数6
ジャーナルCurrent Medicinal Chemistry
10
17
DOI
出版ステータス出版済み - 2003

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子医療
  • 薬理学
  • 創薬
  • 有機化学

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