A potential improvement of rheumatoid arthritis in a patient treated with liraglutide for glucocorticoid-induced diabetes

Michiko Kohno, Masatoshi Nomura, Ichiro Abe, Yusuke Matsumura, yayoi matsuda, Masahiro Adachi, Hisaya Kawate, Ohnaka Keizo, Takahiko Horiuchi, Ryoichi Takayanagi

研究成果: ジャーナルへの寄稿記事

抄録

A 74-year-old male, who had been prescribed prednisolone (PSL) for rheumatoid arthritis (RA) since age 63 and who had developed glucocorticoid-induced diabetes at age 69, was hospitalized due to poor glycemic control. On admission, he was taking 7.5 mg/day of PSL and his Hb Ale was 8.1 % despite infusion of 27 U/day of insulin. As preserved β-cell function was confirmed by a glucagon challenge test, liraglutide therapy was introduced. A stepwise increase in liraglutide successfully improved his glucose tolerance and led to discontinuation of insulin treatment A good glycemic control was finally achieved by the combination of 0.9 mg/day of liraglutide and 3 mg/day of glimepiride. Interestingly, the level of matrix metalloproteinase-3, which indicates the RA activity, was dramatically reduced from 356 ng/m/to 187 ng/m/in parallel with this treatment. The present case may imply that there is a correlation between the administration of glucagon-like peptide-1 and an improvement in the symptoms associated with rheumatoid arthritis.

元の言語英語
ページ(範囲)179-184
ページ数6
ジャーナルJournal of the Japan Diabetes Society
56
発行部数3
出版物ステータス出版済み - 3 1 2013

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Glucocorticoids
Rheumatoid Arthritis
glimepiride
Prednisolone
Insulin
Matrix Metalloproteinase 3
Glucagon-Like Peptide 1
Glucagon
Therapeutics
Glucose
Liraglutide

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

A potential improvement of rheumatoid arthritis in a patient treated with liraglutide for glucocorticoid-induced diabetes. / Kohno, Michiko; Nomura, Masatoshi; Abe, Ichiro; Matsumura, Yusuke; matsuda, yayoi; Adachi, Masahiro; Kawate, Hisaya; Keizo, Ohnaka; Horiuchi, Takahiko; Takayanagi, Ryoichi.

:: Journal of the Japan Diabetes Society, 巻 56, 番号 3, 01.03.2013, p. 179-184.

研究成果: ジャーナルへの寄稿記事

Kohno, Michiko ; Nomura, Masatoshi ; Abe, Ichiro ; Matsumura, Yusuke ; matsuda, yayoi ; Adachi, Masahiro ; Kawate, Hisaya ; Keizo, Ohnaka ; Horiuchi, Takahiko ; Takayanagi, Ryoichi. / A potential improvement of rheumatoid arthritis in a patient treated with liraglutide for glucocorticoid-induced diabetes. :: Journal of the Japan Diabetes Society. 2013 ; 巻 56, 番号 3. pp. 179-184.
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abstract = "A 74-year-old male, who had been prescribed prednisolone (PSL) for rheumatoid arthritis (RA) since age 63 and who had developed glucocorticoid-induced diabetes at age 69, was hospitalized due to poor glycemic control. On admission, he was taking 7.5 mg/day of PSL and his Hb Ale was 8.1 {\%} despite infusion of 27 U/day of insulin. As preserved β-cell function was confirmed by a glucagon challenge test, liraglutide therapy was introduced. A stepwise increase in liraglutide successfully improved his glucose tolerance and led to discontinuation of insulin treatment A good glycemic control was finally achieved by the combination of 0.9 mg/day of liraglutide and 3 mg/day of glimepiride. Interestingly, the level of matrix metalloproteinase-3, which indicates the RA activity, was dramatically reduced from 356 ng/m/to 187 ng/m/in parallel with this treatment. The present case may imply that there is a correlation between the administration of glucagon-like peptide-1 and an improvement in the symptoms associated with rheumatoid arthritis.",
author = "Michiko Kohno and Masatoshi Nomura and Ichiro Abe and Yusuke Matsumura and yayoi matsuda and Masahiro Adachi and Hisaya Kawate and Ohnaka Keizo and Takahiko Horiuchi and Ryoichi Takayanagi",
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AU - Kohno, Michiko

AU - Nomura, Masatoshi

AU - Abe, Ichiro

AU - Matsumura, Yusuke

AU - matsuda, yayoi

AU - Adachi, Masahiro

AU - Kawate, Hisaya

AU - Keizo, Ohnaka

AU - Horiuchi, Takahiko

AU - Takayanagi, Ryoichi

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N2 - A 74-year-old male, who had been prescribed prednisolone (PSL) for rheumatoid arthritis (RA) since age 63 and who had developed glucocorticoid-induced diabetes at age 69, was hospitalized due to poor glycemic control. On admission, he was taking 7.5 mg/day of PSL and his Hb Ale was 8.1 % despite infusion of 27 U/day of insulin. As preserved β-cell function was confirmed by a glucagon challenge test, liraglutide therapy was introduced. A stepwise increase in liraglutide successfully improved his glucose tolerance and led to discontinuation of insulin treatment A good glycemic control was finally achieved by the combination of 0.9 mg/day of liraglutide and 3 mg/day of glimepiride. Interestingly, the level of matrix metalloproteinase-3, which indicates the RA activity, was dramatically reduced from 356 ng/m/to 187 ng/m/in parallel with this treatment. The present case may imply that there is a correlation between the administration of glucagon-like peptide-1 and an improvement in the symptoms associated with rheumatoid arthritis.

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