A Potential VEP Biomarker for Mild Cognitive Impairment: Evidence from Selective Visual Deficit of Higher-Level Dorsal Pathway

Takao Yamasaki, Shizuka Horie, Yasumasa Ohyagi, Eri Tanaka, Norimichi Nakamura, Yoshinobu Goto, Shigenobu Kanba, Jun Ichi Kira, Shozo Tobimatsu, Pravat Mandal

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

抄録

Visual dysfunctions are common in Alzheimer's disease (AD). Our aim was to establish a neurophysiological biomarker for amnestic mild cognitive impairment (aMCI). Visual evoked potentials (VEPs) were recorded in aMCI patients who later developed AD (n=15) and in healthy older (n=15) and younger controls (n=15). Visual stimuli were optimized to separately activate lower and higher levels of the ventral and dorsal streams. We compared VEP parameters across the three groups of participants and conducted a linear correlation analysis between VEPs and data from neuropsychological tests. We then used a receiver operating characteristic (ROC) analysis to discriminate those with aMCI from those who were healthy older adults. The latency and phase of VEPs to lower-level stimuli (chromatic and achromatic gratings) were significantly affected by age but not by cognitive decline. Conversely, VEP latencies for higher-ventral (faces and kanji-words) and dorsal (kana-words and optic flow motion) stimuli were not affected by age, but they were significantly prolonged in aMCI patients. Interestingly, VEPs for higher-dorsal stimuli were related to outcomes of neuropsychological tests. Furthermore, the ROC analysis showed that the highest areas under the curve were obtained for VEP latencies in response to higher-dorsal stimuli. These results suggest aMCI-related functional impairment specific to higher-level visual processing. Further, dysfunction in the higher-level of the dorsal stream could be an early indicator of cognitive decline. Therefore, we conclude that VEPs associated with higher-level dorsal stream activity can be a sensitive biomarker for early detection of aMCI.

元の言語英語
ページ(範囲)661-676
ページ数16
ジャーナルJournal of Alzheimer's Disease
53
発行部数2
DOI
出版物ステータス出版済み - 1 1 2016

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Visual Evoked Potentials
Biomarkers
Neuropsychological Tests
ROC Curve
Optic Flow
Cognitive Dysfunction
Reaction Time
Area Under Curve
Alzheimer Disease
Color

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

これを引用

A Potential VEP Biomarker for Mild Cognitive Impairment : Evidence from Selective Visual Deficit of Higher-Level Dorsal Pathway. / Yamasaki, Takao; Horie, Shizuka; Ohyagi, Yasumasa; Tanaka, Eri; Nakamura, Norimichi; Goto, Yoshinobu; Kanba, Shigenobu; Kira, Jun Ichi; Tobimatsu, Shozo; Mandal, Pravat.

:: Journal of Alzheimer's Disease, 巻 53, 番号 2, 01.01.2016, p. 661-676.

研究成果: ジャーナルへの寄稿記事

Yamasaki, Takao ; Horie, Shizuka ; Ohyagi, Yasumasa ; Tanaka, Eri ; Nakamura, Norimichi ; Goto, Yoshinobu ; Kanba, Shigenobu ; Kira, Jun Ichi ; Tobimatsu, Shozo ; Mandal, Pravat. / A Potential VEP Biomarker for Mild Cognitive Impairment : Evidence from Selective Visual Deficit of Higher-Level Dorsal Pathway. :: Journal of Alzheimer's Disease. 2016 ; 巻 53, 番号 2. pp. 661-676.
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abstract = "Visual dysfunctions are common in Alzheimer's disease (AD). Our aim was to establish a neurophysiological biomarker for amnestic mild cognitive impairment (aMCI). Visual evoked potentials (VEPs) were recorded in aMCI patients who later developed AD (n=15) and in healthy older (n=15) and younger controls (n=15). Visual stimuli were optimized to separately activate lower and higher levels of the ventral and dorsal streams. We compared VEP parameters across the three groups of participants and conducted a linear correlation analysis between VEPs and data from neuropsychological tests. We then used a receiver operating characteristic (ROC) analysis to discriminate those with aMCI from those who were healthy older adults. The latency and phase of VEPs to lower-level stimuli (chromatic and achromatic gratings) were significantly affected by age but not by cognitive decline. Conversely, VEP latencies for higher-ventral (faces and kanji-words) and dorsal (kana-words and optic flow motion) stimuli were not affected by age, but they were significantly prolonged in aMCI patients. Interestingly, VEPs for higher-dorsal stimuli were related to outcomes of neuropsychological tests. Furthermore, the ROC analysis showed that the highest areas under the curve were obtained for VEP latencies in response to higher-dorsal stimuli. These results suggest aMCI-related functional impairment specific to higher-level visual processing. Further, dysfunction in the higher-level of the dorsal stream could be an early indicator of cognitive decline. Therefore, we conclude that VEPs associated with higher-level dorsal stream activity can be a sensitive biomarker for early detection of aMCI.",
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AU - Horie, Shizuka

AU - Ohyagi, Yasumasa

AU - Tanaka, Eri

AU - Nakamura, Norimichi

AU - Goto, Yoshinobu

AU - Kanba, Shigenobu

AU - Kira, Jun Ichi

AU - Tobimatsu, Shozo

AU - Mandal, Pravat

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AB - Visual dysfunctions are common in Alzheimer's disease (AD). Our aim was to establish a neurophysiological biomarker for amnestic mild cognitive impairment (aMCI). Visual evoked potentials (VEPs) were recorded in aMCI patients who later developed AD (n=15) and in healthy older (n=15) and younger controls (n=15). Visual stimuli were optimized to separately activate lower and higher levels of the ventral and dorsal streams. We compared VEP parameters across the three groups of participants and conducted a linear correlation analysis between VEPs and data from neuropsychological tests. We then used a receiver operating characteristic (ROC) analysis to discriminate those with aMCI from those who were healthy older adults. The latency and phase of VEPs to lower-level stimuli (chromatic and achromatic gratings) were significantly affected by age but not by cognitive decline. Conversely, VEP latencies for higher-ventral (faces and kanji-words) and dorsal (kana-words and optic flow motion) stimuli were not affected by age, but they were significantly prolonged in aMCI patients. Interestingly, VEPs for higher-dorsal stimuli were related to outcomes of neuropsychological tests. Furthermore, the ROC analysis showed that the highest areas under the curve were obtained for VEP latencies in response to higher-dorsal stimuli. These results suggest aMCI-related functional impairment specific to higher-level visual processing. Further, dysfunction in the higher-level of the dorsal stream could be an early indicator of cognitive decline. Therefore, we conclude that VEPs associated with higher-level dorsal stream activity can be a sensitive biomarker for early detection of aMCI.

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