A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes

Takao Shimayoshi, Yuta Yamamoto, Tetsuya Matsuda

研究成果: 著書/レポートタイプへの貢献会議での発言

抄録

Intracellular acidosis induced by hypoxia resulted from myocardial ischemia damages myocardium. However, the detailed mechanisms of hypoxic acidosis are not quantitatively explained. The purpose of this study is to create a novel computational model which can reproduce intracellular acidosis caused by myocardial ischemia. We constructed a computational model of myocardium, by using a mathematical ventricular cell model which includes pH regulation and a computational model of myocardial microcirculation for calculating extracellular conditions. The present model reproduced cellular hypoxia in an ischemic condition simulated by a reduced blood flow, and intracellular pH reduction in response to the hypoxia.

元の言語英語
ホスト出版物のタイトル40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
出版者Institute of Electrical and Electronics Engineers Inc.
ページ4540-4543
ページ数4
ISBN(電子版)9781538636466
DOI
出版物ステータス出版済み - 10 26 2018
イベント40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, 米国
継続期間: 7 18 20187 21 2018

出版物シリーズ

名前Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
2018-July
ISSN(印刷物)1557-170X

その他

その他40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
米国
Honolulu
期間7/18/187/21/18

Fingerprint

Acidosis
Cardiac Myocytes
Myocardial Ischemia
Myocardium
Cell Hypoxia
Microcirculation
Blood
Hypoxia

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

これを引用

Shimayoshi, T., Yamamoto, Y., & Matsuda, T. (2018). A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes. : 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (pp. 4540-4543). [8513112] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; 巻数 2018-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8513112

A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes. / Shimayoshi, Takao; Yamamoto, Yuta; Matsuda, Tetsuya.

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 4540-4543 8513112 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; 巻 2018-July).

研究成果: 著書/レポートタイプへの貢献会議での発言

Shimayoshi, T, Yamamoto, Y & Matsuda, T 2018, A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes. : 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018., 8513112, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 巻. 2018-July, Institute of Electrical and Electronics Engineers Inc., pp. 4540-4543, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, 米国, 7/18/18. https://doi.org/10.1109/EMBC.2018.8513112
Shimayoshi T, Yamamoto Y, Matsuda T. A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes. : 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 4540-4543. 8513112. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2018.8513112
Shimayoshi, Takao ; Yamamoto, Yuta ; Matsuda, Tetsuya. / A Preliminary Computational Model for Hypoxic Acidosis in Cardiac Myocytes. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 4540-4543 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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