A preprocessing method for inferring genetic interaction from gene expression data using Boolean algorithm

Kazumi Hakamada, Taizo Hanai, Hiroyuki Honda, Takeshi Kobayashi

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

抄録

Unknown genetic regulation mechanisms are expected to be discovered by information technology using large amount of biological data especially for gene expression data. In this study, we propose a novel inferring method for genetic interactions that combines our original preprocessing method and the Boolean algorithm. First, the performance of our method was evaluated using artificial data. The results showed that our method was able to infer genetic interactions with high specificity (specificity=0.629). Then, using our method, the genetic interaction was inferred from the experimental time course data collected using microarray on 69 genes of cell cycle for Saccharomyces cerevisiae. Our method estimated about 80% of all genetic interactions in Kyoto Encyclopedia Genes and Genomes (KEGG) for these genes. Furthermore, our method was able to infer several other genetic interactions that are not included in KEGG but whose existence is supported by other biological reports.

元の言語英語
ページ(範囲)457-463
ページ数7
ジャーナルJournal of Bioscience and Bioengineering
98
発行部数6
DOI
出版物ステータス出版済み - 1 1 2004

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Gene expression
Genes
Gene Expression
Encyclopedias
Genome
cdc Genes
Microarrays
Yeast
Information technology
Saccharomyces cerevisiae
Cells
Technology

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

これを引用

A preprocessing method for inferring genetic interaction from gene expression data using Boolean algorithm. / Hakamada, Kazumi; Hanai, Taizo; Honda, Hiroyuki; Kobayashi, Takeshi.

:: Journal of Bioscience and Bioengineering, 巻 98, 番号 6, 01.01.2004, p. 457-463.

研究成果: ジャーナルへの寄稿記事

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