A progression to dermatofibrosarcoma protuberans with a fibrosarcomatous component: A special reference to the chromosomal aberrations

Manabu Hamada, Naoya Hirakawa, Toshiro Fukuda, Masutaka Furue, Yoshiaki Hori, Masazumi Tsuneyoshi

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)


Dermatofibrosarcoma protuberans (DFSP) with fibrosarcomatous areas (DFSP-FS) is differentiated from ordinary DFSP by its unfavourable prognosis. We carried out sequential analysis of numerical chromosomal abnormalities in two cases of DFSP during their progression to metastatic disease with FS areas (DFSP-M-FS). They were compared with nine cases of ordinary DFSP and three cases of DFSP-FS, but without metastases. Numerical chromosomal changes were examined by fluorescence in situ hybridization (FISH) using alpha-satellite centromeric probes for chromosomes 1, 8, 11 and 17. Numerical imbalances of chromosome 1 were not clarified. A gain of chromosome 8 was demonstrated in the two cases of DFSP-M-FS. A gain of chromosome 11 was observed in one of the two cases of DFSP-M-FS and in one case of DFSP-FS. A gain of chromosome 17 was demonstrated in both metastatic tumours and in recurrent tumours in two cases of DFSP-M-FS, in addition to two cases of DFSP-FS and four cases of ordinary DFSP with recurrent tumours or large tumours. This study raised the hypothesis that a gain of chromosome 17 developed in recurrent or large-sized DFSP, which occurs in high-risk groups with the possibility of a progression to FS.

ジャーナルPathology Research and Practice
出版物ステータス出版済み - 1 1 1999


All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Cell Biology