A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus

Hironaka Tsunobuchi, Hitoshi Nishimura, Fumi Goshima, Tohru Daikoku, Haruhiko Suzuki, Izumi Nakashima, Yukihiro Nishiyama, Yasunobu Yoshikai

    研究成果: ジャーナルへの寄稿記事

    39 引用 (Scopus)

    抄録

    To define the role of cytokine binding to the IL-2/IL-15Rβ chain in protective immunity against systemic infection with herpes simplex virus type 2 (HSV-2), IL-2/IL-15 receptor(R)β knock-out mice were inoculated intraperitoneally with HSV-2 strain 186. IL-2/IL-15Rβ-deficient mice were susceptible to systemic HSV-2 infection compared with their heterozygous littermates. The emergence of natural killer (NK) cells was impaired in IL-2/IL-15Rβ knock-out mice, but CD4+ T cell receptor (TOR) αβ+ T cells were normally detected in the peritoneal cavity after infection with HSV-2. However, the generation of HSV-2-specific CD4+ T helper (Th) 1 cells producing interferon-γ was impaired in IL-2/IL-15Rβ knock-out mice following HSV-2 infection. The serum IL-15 level in control mice was increased in the early stage after HSV-2 infection but was not detectable in IL-2/IL-15Rβ knock-out mice. In vivo administration of recombinant IL-15 protected normal mice from HSV-2-induced lethality, accompanied by increases in numbers of NK cells and HSV-2-specific Th1 cells. Taken together, these results suggest that IL-15, using the IL-2/IL15Rβ chain, plays an important role in mounting protective immunity during the course of systemic HSV-2 infection. (C) 2000 Academic Press.

    元の言語英語
    ページ(範囲)57-66
    ページ数10
    ジャーナルVirology
    275
    発行部数1
    DOI
    出版物ステータス出版済み - 9 15 2000

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    Interleukin-15
    Human Herpesvirus 2
    Simplexvirus
    Interleukin-2
    Infection
    Virus Diseases
    Knockout Mice
    Th1 Cells
    Natural Killer Cells
    Immunity
    Interleukin-15 Receptors
    Peritoneal Cavity
    T-Cell Antigen Receptor
    Interferons
    Cytokines
    T-Lymphocytes

    All Science Journal Classification (ASJC) codes

    • Virology

    これを引用

    Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., ... Yoshikai, Y. (2000). A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology, 275(1), 57-66. https://doi.org/10.1006/viro.2000.0455

    A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. / Tsunobuchi, Hironaka; Nishimura, Hitoshi; Goshima, Fumi; Daikoku, Tohru; Suzuki, Haruhiko; Nakashima, Izumi; Nishiyama, Yukihiro; Yoshikai, Yasunobu.

    :: Virology, 巻 275, 番号 1, 15.09.2000, p. 57-66.

    研究成果: ジャーナルへの寄稿記事

    Tsunobuchi, H, Nishimura, H, Goshima, F, Daikoku, T, Suzuki, H, Nakashima, I, Nishiyama, Y & Yoshikai, Y 2000, 'A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus', Virology, 巻. 275, 番号 1, pp. 57-66. https://doi.org/10.1006/viro.2000.0455
    Tsunobuchi H, Nishimura H, Goshima F, Daikoku T, Suzuki H, Nakashima I その他. A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. Virology. 2000 9 15;275(1):57-66. https://doi.org/10.1006/viro.2000.0455
    Tsunobuchi, Hironaka ; Nishimura, Hitoshi ; Goshima, Fumi ; Daikoku, Tohru ; Suzuki, Haruhiko ; Nakashima, Izumi ; Nishiyama, Yukihiro ; Yoshikai, Yasunobu. / A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus. :: Virology. 2000 ; 巻 275, 番号 1. pp. 57-66.
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