A protein kinase signal-responsive gene carrier modified RGD peptide

Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

抄録

We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

元の言語英語
ページ(範囲)5740-5743
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
16
発行部数22
DOI
出版物ステータス出版済み - 11 15 2006

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Protein Kinases
Polymers
Genes
Gene expression
Cells
Synthetic Genes
Cyclic AMP-Dependent Protein Kinases
Chemical activation
Gene Expression
arginyl-glycyl-aspartic acid
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

これを引用

A protein kinase signal-responsive gene carrier modified RGD peptide. / Oishi, Jun; Ijuin, Moeko; Sonoda, Tatsuhiko; Kang, Jeong Hun; Kawamura, Kenji; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki.

:: Bioorganic and Medicinal Chemistry Letters, 巻 16, 番号 22, 15.11.2006, p. 5740-5743.

研究成果: ジャーナルへの寄稿記事

Oishi, Jun ; Ijuin, Moeko ; Sonoda, Tatsuhiko ; Kang, Jeong Hun ; Kawamura, Kenji ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki. / A protein kinase signal-responsive gene carrier modified RGD peptide. :: Bioorganic and Medicinal Chemistry Letters. 2006 ; 巻 16, 番号 22. pp. 5740-5743.
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