TY - JOUR
T1 - A randomized, placebo-controlled study on the safety and efficacy of daily ingestion of green tea (Camellia sinensis l.) cv. “Yabukita” and “Sunrouge” on eyestrain and blood pressure in healthy adults
AU - Maeda-Yamamoto, Mari
AU - Nishimura, Mie
AU - Kitaichi, Nobuyoshi
AU - Nesumi, Atsushi
AU - Monobe, Manami
AU - Nomura, Sachiko
AU - Horie, Yukihiro
AU - Tachibana, Hirofumi
AU - Nishihira, Jun
N1 - Funding Information:
Acknowledgments: The authors would like to thank Kaori Ema of the NARO Institute of Fruit and Tea Science for her valuable assistance in the research and data analysis. This study was supported by a grant-in-aid “A scheme of Revitalizing Agriculture and Fisheries in Disaster Area through Deploying Highly Advanced Technology” from of the Ministry of Agriculture, Forestry and Fisheries of Japan.
Publisher Copyright:
© 2018 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2018/5
Y1 - 2018/5
N2 - The green tea (Camellia sinensis L.) cultivar “Sunrouge” contains anthocyanins, catechins and flavonols. To determine whether ingesting green tea containing anthocyanins improves visual function and blood pressure (BP) in healthy adults, a randomized, double-blind, placebo-controlled study was performed. A total of 120 healthy subjects, aged between 20 and 60 years and with a systolic BP (SBP) value of ≤125 and <155 and a diastolic BP (DBP) value <95, or a DBP of ≤75 mmHg and <95 mmHg and a SBP <155 mmHg, were randomly assigned to one of three groups. For 12 weeks, the placebo group received barley extract without catechin; another group received “Sunrouge” extract containing 11.2 mg anthocyanin and 323.6 mg epigallocatechin-3-O-gallate (EGCG); and a third group received “Yabukita” extract containing 322.2 mg EGCG. Home BP, accommodation ability, visual analog scale questionnaires for eyestrain, and metabolic-associated markers were analyzed at weeks 0, 4, 8, and 12 of the intake period. The ingestion of “Sunrouge” tea significantly improved accommodation ability and eyestrain in subjects younger than 45 years and in subjects who operated visual display terminals every day. It also elevated BP. “Yabukita” tea ingestion significantly increased serum adiponectin levels. No adverse effects were observed. We conclude that long-term intake of “Sunrouge” tea containing anthocyanins and flavonols might improve visual function.
AB - The green tea (Camellia sinensis L.) cultivar “Sunrouge” contains anthocyanins, catechins and flavonols. To determine whether ingesting green tea containing anthocyanins improves visual function and blood pressure (BP) in healthy adults, a randomized, double-blind, placebo-controlled study was performed. A total of 120 healthy subjects, aged between 20 and 60 years and with a systolic BP (SBP) value of ≤125 and <155 and a diastolic BP (DBP) value <95, or a DBP of ≤75 mmHg and <95 mmHg and a SBP <155 mmHg, were randomly assigned to one of three groups. For 12 weeks, the placebo group received barley extract without catechin; another group received “Sunrouge” extract containing 11.2 mg anthocyanin and 323.6 mg epigallocatechin-3-O-gallate (EGCG); and a third group received “Yabukita” extract containing 322.2 mg EGCG. Home BP, accommodation ability, visual analog scale questionnaires for eyestrain, and metabolic-associated markers were analyzed at weeks 0, 4, 8, and 12 of the intake period. The ingestion of “Sunrouge” tea significantly improved accommodation ability and eyestrain in subjects younger than 45 years and in subjects who operated visual display terminals every day. It also elevated BP. “Yabukita” tea ingestion significantly increased serum adiponectin levels. No adverse effects were observed. We conclude that long-term intake of “Sunrouge” tea containing anthocyanins and flavonols might improve visual function.
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U2 - 10.3390/nu10050569
DO - 10.3390/nu10050569
M3 - Article
C2 - 29734777
AN - SCOPUS:85046646913
VL - 10
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 5
M1 - 569
ER -