A sellar neuroblastoma showing rapid growth and causing syndrome of inappropriate secretion of antidiuretic hormone: A case report

Muhammad Kamil, Nayuta Higa, Hajime Yonezawa, Shingo Fujio, Jun Sugata, Tomoko Takajo, Tsubasa Hiraki, Junko Hirato, Kazunori Arita, Koji Yoshimoto

研究成果: Contribution to journalArticle査読

抄録

Background: Sellar neuroblastoma is a very rare entity. We report a rare case of arginine vasopressin (AVP)-producing sellar neuroblastoma presumed to have originated from the lower part of sellar turcica, which grew very rapidly. Case Description: A 33-year-old woman was found to have a sellar lesion with a diameter of 18 mm invading into the bilateral cavernous sinus on magnetic resonance imaging (MRI) performed for dizziness. Six years later, when she visited the clinic due to bilateral visual disturbance, MRI showed a rapid growth of the tumor, with a maximal diameter of 56 mm at the current state, strongly compressing the optic nerve and chiasm. Transsphenoidal decompression of the optic chiasm revealed an intact pituitary gland on the top of the tumor. The tumor was composed of neoplastic cells that were immunohistochemically positive for neuronal markers and arginine vasopressin (AVP), but negative for all anterior pituitary hormones, glial fibrillary acidic protein, or thyroid transcription factor-1; these findings were suggestive of sellar neuroblastoma. She underwent 50-Gy radiation therapy, which has controlled the growth for the past 3 years. Conclusion: Awareness of rare sellar neuroblastomas will allow the accumulation of clinicopathologic information that may facilitate the understanding of their origin, clinical features, neuroimaging characteristics, and pertinent adjuvant treatment.

本文言語英語
論文番号25259
ジャーナルSurgical Neurology International
11
DOI
出版ステータス出版済み - 6 27 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 外科
  • 臨床神経学

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