A short history of research on immunity to infectious diseases in fish

Willem B. Van Muiswinkel, Miki Nakao

研究成果: ジャーナルへの寄稿評論記事

35 引用 (Scopus)

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This review describes the history of research on immunity to infectious diseases of fish in the period between 1965 and today. Special attention is paid to those studies, which are dealing with the interaction between immune system and invading pathogens in bony fish. Moreover, additional biographic information will be provided of people involved. In the 1960s and 1970s the focus of most studies was on humoral (Ig, B-cell) responses. Thorough studies on specific cellular (T-cell) responses and innate immunity (lectins, lysozyme, interferon, phagocytic cells) became available later. In the period between 1980 and today an overwhelming amount of data on regulation (e.g. cell cooperation, cytokines) and cell surface receptors (e.g. T-cell receptor; MHC) was published. It became also clear, that innate responses were often interacting with the acquired immune responses. Fish turned out to be vertebrates like all others with a sophisticated immune system showing specificity and memory. These basic data on the immune system could be applied in vaccination or in selection of disease resistant fish. Successful vaccines against bacterial diseases became available in the 1970s and 1980s. Effective anti-viral vaccines appeared from the 1980s onwards. There is no doubt, that Fish Immunology has become a flourishing science by the end of the 20th century and has contributed to our understanding of fish diseases as well as the success of aquaculture.

元の言語英語
ページ(範囲)130-150
ページ数21
ジャーナルDevelopmental and Comparative Immunology
43
発行部数2
DOI
出版物ステータス出版済み - 4 1 2014

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

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