A short scalable route to (-)-α-kainic acid using Pt-catalyzed direct allylic amination

Ming Zhang, Kenji Watanabe, Masafumi Tsukamoto, Ryozo Shibuya, Hiroyuki Morimoto, Takashi Ohshima

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

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An increased supply of scarce or inaccessible natural products is essential for the development of more sophisticated pharmaceutical agents and biological tools, and thus the development of atom-economical, step-economical and scalable processes to access these natural products is in high demand. Herein we report the development of a short, scalable total synthesis of (-)-α-kainic acid, a useful compound in neuropharmacology that is, however, limited in supply from natural resources. The synthesis features sequential platinum-catalyzed direct allylic aminations and thermal ene-cyclization, enabling the gram-scale synthesis of (-)-α-kainic acid in six steps and 34% overall yield.

元の言語英語
ページ(範囲)3937-3941
ページ数5
ジャーナルChemistry - A European Journal
21
発行部数10
DOI
出版物ステータス出版済み - 10 7 2014

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

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