This research aims to optimize configuration, arrangement, and operation of distributed energy supply systems based on energy demands in a business area. We developed a method to estimate the five-minute energy demand of power and heat (heating, cooling and hot water) of non-residential buildings for one year. This method formulated each demand from the standard amount based on statistical and measurement data, by changing it and reproducing the actual fluctuations according to the type of buildings, total floor area, outdoor air temperature and a random number simulation. Furthermore, we estimated energy demands of dozens of buildings in the business area of Japan. Moreover, we set distributed energy supply systems (photovoltaic power generation system, combined heat and power, storage batteries) on these buildings and studied best configuration and operation of these energy systems. This study confirmed that an energy aggregation by introducing a HIC is more suitable than the optimization in individual buildings depending on the purpose.