A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

The Tabula Muris Consortium

研究成果: Contribution to journalArticle査読

111 被引用数 (Scopus)

抄録

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death1. Despite rapid advances over recent years, many of the molecular and cellular processes that underlie the progressive loss of healthy physiology are poorly understood2. To gain a better insight into these processes, here we generate a single-cell transcriptomic atlas across the lifespan of Mus musculus that includes data from 23 tissues and organs. We found cell-specific changes occurring across multiple cell types and organs, as well as age-related changes in the cellular composition of different organs. Using single-cell transcriptomic data, we assessed cell-type-specific manifestations of different hallmarks of ageing—such as senescence3, genomic instability4 and changes in the immune system2. This transcriptomic atlas—which we denote Tabula Muris Senis, or ‘Mouse Ageing Cell Atlas’—provides molecular information about how the most important hallmarks of ageing are reflected in a broad range of tissues and cell types.

本文言語英語
ページ(範囲)590-595
ページ数6
ジャーナルNature
583
7817
DOI
出版ステータス出版済み - 7 23 2020

All Science Journal Classification (ASJC) codes

  • 一般

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