A single intraduodenal administration of human adenovirus 40 vaccine effectively prevents anaphylactic shock

Satoshi Yamasaki, Yoshiaki Miura, Julia Davydov, Selwyn M. Vickers, Masato Yamamoto

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Vaccine administration into the intestine is known to induce mucosal tolerance most efficiently. Therefore, developing a delivery system that targets the intestinal mucosa is expected to improve the efficiency of immunosuppression. Human enteric adenovirus serotype 40 (Ad40)-based vectors have the advantage of targeting intestinal mucosa, making them prime candidates as mucosal vaccine carriers for immunosuppression. Here, after both oral and intraduodenal administrations, the vector distribution of replication-defective recombinant Ad40 vectors (rAd40) was significantly higher than that of a conventional Ad vector based on human adenovirus 5 (Ad5) in ilea containing Peyer's patches. Single intraduodenal administration of rAd40 induced antigen-specific mucosal immunoreaction mediated by intestinal mucosal and systemic immunity. In ovalbumin-induced allergy mouse models, this approach inhibited antigen-specific delayed-type hypersensitivity reactions, diarrhea occurrence, and systemic anaphylaxis. Thus, a single intraduodenal administration of rAd40 provides a potent method of inducing allergen-specific mucosal tolerance and a new allergen-specific immunotherapy for overcoming problems with current therapies against life-threatening allergic reactions, including anaphylaxis.

本文言語英語
ページ(範囲)1508-1516
ページ数9
ジャーナルClinical and Vaccine Immunology
20
10
DOI
出版ステータス出版済み - 10 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 臨床生化学
  • 微生物学(医療)

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