A small modulatory dsRNA specifies the fate of adult neural stem cells

Tomoko Kuwabara, Jenny Hsieh, Kinichi Nakashima, Kazunari Taira, Fred H. Gage

研究成果: ジャーナルへの寄稿学術誌査読

379 被引用数 (Scopus)

抄録

Discovering the molecular mechanisms that regulate neuron-specific gene expression remains a central challenge for CNS research. Here, we report that small, noncoding double-stranded (ds) RNAs play a critical role in mediating neuronal differentiation. The sequence defined by this dsRNA is NRSE/RE1, which is recognized by NRSF/REST, known primarily as a negative transcriptional regulator that restricts neuronal gene expression to neurons. The NRSE dsRNA can trigger gene expression of neuron-specific genes through interaction with NRSF/REST transcriptional machinery, resulting in the transition from neural stem cells with neuron-specific genes silenced by NRSF/REST into cells with neuronal identity that can express neuronal genes. The mechanism of action appears to be mediated through a dsRNA/protein interaction, rather than through siRNA or miRNA. The discovery of small modulatory dsRNAs (smRNAs) extends the important contribution of noncoding RNAs as key regulators of cell behavior at both transcriptional and posttranscriptional levels.

本文言語英語
ページ(範囲)779-793
ページ数15
ジャーナルCell
116
6
DOI
出版ステータス出版済み - 3月 19 2004
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)

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