A small-sized lipid nanoparticles production method using microfluidic devices with baffle structures

Niko Kimura, Masatoshi Maeki, Yusuke Note, Yusuke Sato, Akihiko Ishida, Hirofumi Tani, Hideyoshi Harashima, Manabu Tokeshi

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

This paper reports a lipid nanoparticles (LNP) production method and its formation behavior using microfluidic devices with baffle structures. The microfluidic devices showed great mixing efficiency at 500 μL/min, and we achieved 20 nm-sized LNPs production that chaotic micromixers were not able to produce at the same flow rate condition. Additionally, we found that the smaller-sized LNPs/siRNA prepared by baffle structures have higher penetration efficiency than that of the larger-sized LNPs, but all of them showed the gene silencing activity. The microfluidic devices with baffle structures are expected to be a practicable apparatus for DDSs application.

本文言語英語
ホスト出版物のタイトル21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
出版社Chemical and Biological Microsystems Society
ページ965-966
ページ数2
ISBN(電子版)9780692941836
出版ステータス出版済み - 2020
外部発表はい
イベント21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, 米国
継続期間: 10月 22 201710月 26 2017

出版物シリーズ

名前21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

会議

会議21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
国/地域米国
CitySavannah
Period10/22/1710/26/17

!!!All Science Journal Classification (ASJC) codes

  • 化学工学(その他)
  • バイオエンジニアリング

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