A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

Jeong Hun Kang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

    研究成果: Contribution to journalArticle査読

    7 被引用数 (Scopus)

    抄録

    A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.

    本文言語英語
    ページ(範囲)336-339
    ページ数4
    ジャーナルVeterinary Journal
    181
    3
    DOI
    出版ステータス出版済み - 9 2009

    All Science Journal Classification (ASJC) codes

    • Animal Science and Zoology
    • veterinary(all)

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