A Toll-like receptor in horseshoe crabs

Kei Ichiro Inamori, Shigeru Ariki, Shun-Ichiro Kawabata

研究成果: Contribution to journalReview article査読

37 被引用数 (Scopus)

抄録

Non-self-recognition of invading microbes relies on the pattern-recognition of pathogen-associated molecular patterns (PAMPs) derived from microbial cell-wall components. Insects and mammals conserve a signaling pathway of the innate immune system through cell-surface receptors called Tolls and Toll-like receptors (TLRs). Bacterial lipopolysaccharides (LPSs) are an important trigger of the horseshoe crab's innate immunity to infectious microorganisms. Horseshoe crabs' granular hemocytes respond specifically to LPS stimulation, inducing the secretion of various defense molecules from the granular hemocytes. Here, we show a cDNA which we named tToll, coding for a TLR identified from hemocytes of the horseshoe crab Tachypleus tridentatus. tToll is most closely related to Drosophila Toll in both domain architecture and overall length. Human TLRs have been suggested tc contain numerous PAMP-binding insertions located in the leucine-rich repeats (LRRs) of their ectodomains. However, the LRRs of tToll contained no obvious PAMP-binding insertions. Furthermore, tToll was non-specifically expressed in horseshoe crab tissues. These observations suggest that tToll does not function as an LPS receptor on granular hemocytes.

本文言語英語
ページ(範囲)106-115
ページ数10
ジャーナルImmunological Reviews
198
DOI
出版ステータス出版済み - 4 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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