A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction

Isao Shimokawa, Masanori Utsuyama, Toshimitsu Komatsu, Haruyoshi Yamaza, Takuya Chiba

研究成果: 著書/レポートタイプへの貢献

1 引用 (Scopus)

抄録

Immunosenescence or dysregulation of the immune system may accelerate the aging process and shorten the lifespan in animals. Calorie restriction, a well-known nutritional intervention for longevity in laboratory animals, retards immunosenescence and modulates the immunosystem. These effects of CR could contribute partly to extending the lifespan. A transgenic (Tg) dwarf rat strain, in which the growth hormone (GH) axis is selectively suppressed, lived longer and exhibited several phenotypes similar to those in CR rats, suggesting an important role for the GH axis in the effect of CR. Here, we describe the longevity, pathology, thymic and splenic lymphocyte subpopulations and response to endotoxin in Tg rats in comparison with CR rats. The findings support the importance of the GH axis in the effect of CR on the immune system and, in particular, longevity. The Tg rats could be a useful tool to better understand the molecular mechanisms underlying the antiaging effect of CR.

元の言語英語
ホスト出版物のタイトルHandbook on Immunosenescence
ホスト出版物のサブタイトルBasic Understanding and Clinical Applications
出版者Springer Netherlands
ページ131-144
ページ数14
ISBN(電子版)9781402090639
ISBN(印刷物)9781402090622
DOI
出版物ステータス出版済み - 1 1 2009

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Transgenic Rats
Growth Hormone
Immune System
Lymphocyte Subsets
Laboratory Animals
Endotoxins
Pathology
Phenotype
Immunosenescence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Shimokawa, I., Utsuyama, M., Komatsu, T., Yamaza, H., & Chiba, T. (2009). A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. : Handbook on Immunosenescence: Basic Understanding and Clinical Applications (pp. 131-144). Springer Netherlands. https://doi.org/10.1007/978-1-4020-9063-9-7

A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. / Shimokawa, Isao; Utsuyama, Masanori; Komatsu, Toshimitsu; Yamaza, Haruyoshi; Chiba, Takuya.

Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. p. 131-144.

研究成果: 著書/レポートタイプへの貢献

Shimokawa, I, Utsuyama, M, Komatsu, T, Yamaza, H & Chiba, T 2009, A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. : Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, pp. 131-144. https://doi.org/10.1007/978-1-4020-9063-9-7
Shimokawa I, Utsuyama M, Komatsu T, Yamaza H, Chiba T. A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. : Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands. 2009. p. 131-144 https://doi.org/10.1007/978-1-4020-9063-9-7
Shimokawa, Isao ; Utsuyama, Masanori ; Komatsu, Toshimitsu ; Yamaza, Haruyoshi ; Chiba, Takuya. / A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction. Handbook on Immunosenescence: Basic Understanding and Clinical Applications. Springer Netherlands, 2009. pp. 131-144
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