A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[: A, c] phenazine for detection of superoxide anions and its application in cell imaging

Ji Yang, Xianglong Liu, Honglei Wang, Haoqi Tan, Xiaoxu Xie, Xiao Zhang, Chenchen Liu, Xue Qu, Jianli Hua

研究成果: ジャーナルへの寄稿学術誌査読

29 被引用数 (Scopus)

抄録

A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.

本文言語英語
ページ(範囲)1242-1249
ページ数8
ジャーナルAnalyst
143
5
DOI
出版ステータス出版済み - 3月 7 2018
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 環境化学
  • 分光学
  • 電気化学

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