Aaptamine-related alkaloid from the marine sponge aaptos aaptos

Toshiyuki Hamada, Yoshito Matsumoto, Chin Soon Phan, Takashi Kamada, Satoaki Onitsuka, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima, Fumito Tani, Charles S. Vairappan

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.

本文言語英語
ページ(範囲)1-3
ページ数3
ジャーナルNatural product communications
14
9
DOI
出版ステータス出版済み - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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