Aaptamine-related alkaloid from the marine sponge aaptos aaptos

Toshiyuki Hamada, Yoshito Matsumoto, Chin Soon Phan, Takashi Kamada, Satoaki Onitsuka, Hiroaki Okamura, Tetsuo Iwagawa, Naomichi Arima, Fumito Tani, Charles S. Vairappan

研究成果: Contribution to journalArticle

3 引用 (Scopus)


A new aaptamine-related alkaloid, 1,3-dioxolo [4,5-d] benzo [de]-1,6-naphthyridine (methylenedioxyaaptamine, 1), was isolated from the organic extracts of the Bornean marine sponge Aaptos aaptos, together with a known aaptamine derivative, 8,9,9-trime-thoxy-9H-benzo [de]-1,6-naphthyridine (2). The structure of compound 1 was elucidated by interpretation of its spectroscopic data. Two compounds were tested for their cytotoxic potentials against adult T-cell leukemia (ATL) cells, and compound 1 showed moderate cytotoxic potential.

ジャーナルNatural product communications
出版物ステータス出版済み - 1 1 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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    Hamada, T., Matsumoto, Y., Phan, C. S., Kamada, T., Onitsuka, S., Okamura, H., Iwagawa, T., Arima, N., Tani, F., & Vairappan, C. S. (2019). Aaptamine-related alkaloid from the marine sponge aaptos aaptos. Natural product communications, 14(9), 1-3. https://doi.org/10.1177/1934578X19863935