Aberrant HS1 molecule in a patient with systemic lupus erythematosus

T. Sawabe, T. Horiuchi, R. Koga, H. Tsukamoto, T. Kojima, T. Harashima, Y. Kikuchi, J. Otsuka, H. Mitoma, S. Yoshizawa, Y. Niho, T. Watanabe

研究成果: Contribution to journalReview article査読

13 被引用数 (Scopus)

抄録

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive B lymphocytes, which are supposed to carry aberrant signal transduction after the stimulation of B-cell receptor (BCR). To investigate abnormalities in BCR-mediated signaling pathway in lupus B lymphocytes, we analyzed HS1, a molecule downstream of BCR, in 80 Japanese SLE patients. We identified 37 amino acid deletion of HS1 in a 25-year-old female patient, and the aberrant HS1 lacked a part of a functional motif. Analysis of genomic DNA revealed that the aberrant HS1 was caused by exon skipping. Family study showed that the patient as well as her father and sister are heterozygous for the abnormality. WEHI-231 cell, a mouse B cell line, transfected with the aberrant HS1 displayed a significantly increased cell death upon cross-linking of BCR. Additionally, peripheral B lymphocytes from the patient exerted increased apoptosis after BCR stimulation compared to those from control SLE patients. These data suggest that the aberrant HS1 molecule may transmit an accelerated signal after BCR stimulation and may play a role in the activation of autoreactive B lymphocytes.

本文言語英語
ページ(範囲)122-131
ページ数10
ジャーナルGenes and Immunity
4
2
DOI
出版ステータス出版済み - 3 2003

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 遺伝学
  • 遺伝学(臨床)

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