Abnormalities of cardiac sympathetic neuronal and left ventricular function in chronic mitral regurgitation: Assessment by iodine-123 metaiodobenzylguanidine scintigraphy

H. Tsutsui, S. Ando -i., T. Kubota, M. Kuroiwa-Matsumoto, K. Egashira, M. Sasaki, Y. Kuwabara, S. Koyanagi, H. Yasui, A. Takeshita

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Myocardial uptake of iodine-123 meta-iodobenzylguanidine (123I-MIBG) was measured using scintigrams at rest in 12 patients with isolated, nonischemic mitral regurgitation (MR; regurgitant fraction 64% ± 7%) and was related to the left ventricular (LV) function assessed by cardiac catheterization. Iodine-123 meta-iodobenzylguanidine activity at the upper mediastinum, liver, and lung was comparable between MR and control (n = 8) patients. The heart to mediastinum 123I-MIBG activity ratio 4 hours after injection was significantly (p < 0.01) decreased in MR (2.0 ± 0.1, mean ± SE) compared with control (2.7 ± 0.1) with the increased clearance of MIBG. In addition, MR patients had significantly greater heterogeneity in the 123I-MIBG distribution within the myocardial images (26.1% ± 2.1% intraimage variability for MR versus 15.6% ± 0.8% for control, p < 0.01). Myocardial 123I-MIBG activity correlated positively with cardiac index and negatively with pulmonary capillary wedge pressure and LV volume indexes. Thus, 123I-MIBG scintigrams can be a noninvasive method for assessing the contractile dysfunction in MR.

元の言語英語
ページ(範囲)14-22
ページ数9
ジャーナルAmerican Journal of Cardiac Imaging
10
発行部数1
出版物ステータス出版済み - 2 29 1996

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3-Iodobenzylguanidine
Mitral Valve Insufficiency
Left Ventricular Function
Radionuclide Imaging
Iodine
Mediastinum
Pulmonary Wedge Pressure
Cardiac Catheterization
Lung
Injections
Liver

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

これを引用

Abnormalities of cardiac sympathetic neuronal and left ventricular function in chronic mitral regurgitation : Assessment by iodine-123 metaiodobenzylguanidine scintigraphy. / Tsutsui, H.; Ando -i., S.; Kubota, T.; Kuroiwa-Matsumoto, M.; Egashira, K.; Sasaki, M.; Kuwabara, Y.; Koyanagi, S.; Yasui, H.; Takeshita, A.

:: American Journal of Cardiac Imaging, 巻 10, 番号 1, 29.02.1996, p. 14-22.

研究成果: ジャーナルへの寄稿記事

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abstract = "Myocardial uptake of iodine-123 meta-iodobenzylguanidine (123I-MIBG) was measured using scintigrams at rest in 12 patients with isolated, nonischemic mitral regurgitation (MR; regurgitant fraction 64{\%} ± 7{\%}) and was related to the left ventricular (LV) function assessed by cardiac catheterization. Iodine-123 meta-iodobenzylguanidine activity at the upper mediastinum, liver, and lung was comparable between MR and control (n = 8) patients. The heart to mediastinum 123I-MIBG activity ratio 4 hours after injection was significantly (p < 0.01) decreased in MR (2.0 ± 0.1, mean ± SE) compared with control (2.7 ± 0.1) with the increased clearance of MIBG. In addition, MR patients had significantly greater heterogeneity in the 123I-MIBG distribution within the myocardial images (26.1{\%} ± 2.1{\%} intraimage variability for MR versus 15.6{\%} ± 0.8{\%} for control, p < 0.01). Myocardial 123I-MIBG activity correlated positively with cardiac index and negatively with pulmonary capillary wedge pressure and LV volume indexes. Thus, 123I-MIBG scintigrams can be a noninvasive method for assessing the contractile dysfunction in MR.",
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AU - Kubota, T.

AU - Kuroiwa-Matsumoto, M.

AU - Egashira, K.

AU - Sasaki, M.

AU - Kuwabara, Y.

AU - Koyanagi, S.

AU - Yasui, H.

AU - Takeshita, A.

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AB - Myocardial uptake of iodine-123 meta-iodobenzylguanidine (123I-MIBG) was measured using scintigrams at rest in 12 patients with isolated, nonischemic mitral regurgitation (MR; regurgitant fraction 64% ± 7%) and was related to the left ventricular (LV) function assessed by cardiac catheterization. Iodine-123 meta-iodobenzylguanidine activity at the upper mediastinum, liver, and lung was comparable between MR and control (n = 8) patients. The heart to mediastinum 123I-MIBG activity ratio 4 hours after injection was significantly (p < 0.01) decreased in MR (2.0 ± 0.1, mean ± SE) compared with control (2.7 ± 0.1) with the increased clearance of MIBG. In addition, MR patients had significantly greater heterogeneity in the 123I-MIBG distribution within the myocardial images (26.1% ± 2.1% intraimage variability for MR versus 15.6% ± 0.8% for control, p < 0.01). Myocardial 123I-MIBG activity correlated positively with cardiac index and negatively with pulmonary capillary wedge pressure and LV volume indexes. Thus, 123I-MIBG scintigrams can be a noninvasive method for assessing the contractile dysfunction in MR.

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