TY - JOUR
T1 - Abnormalities of the Wnt/β-catenin signalling pathway induce tumour progression in sporadic desmoid tumours
T2 - Correlation between β-catenin widespread nuclear expression and VEGF overexpression
AU - Matono, Hiroshi
AU - Tamiya, Sadafumi
AU - Yokoyama, Ryohei
AU - Saito, Tsuyoshi
AU - Iwamoto, Yukihide
AU - Tsuneyoshi, Masazumi
AU - Oda, Yoshinao
PY - 2011/9
Y1 - 2011/9
N2 - Aims: To analyse the correlation between β-catenin and vascular endothelial growth factor (VEGF) in sporadic desmoid tumours. Methods and results: The correlation between β-catenin aberrant expression and VEGF overexpression was examined and microvessel density (MVD) assessed by immunohistochemical expression of CD31 in 74 samples (63 primary and 11 recurrent samples, 63 patients) of sporadic desmoid tumours without familial adenomatous polyposis (FAP). β-catenin gene mutation and mRNA expression of VEGF was then examined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). There was a statistically significant correlation between widespread nuclear expression of β-catenin and overexpression of VEGF in all desmoid tumours (P=0.04, Fisher's exact test). MVD in recurrent tumours was significantly higher than that in primary tumours. Conclusions: Abnormalities of β-catenin and VEGF overexpression play an important role in the neoplastic progression of sporadic desmoid tumours.
AB - Aims: To analyse the correlation between β-catenin and vascular endothelial growth factor (VEGF) in sporadic desmoid tumours. Methods and results: The correlation between β-catenin aberrant expression and VEGF overexpression was examined and microvessel density (MVD) assessed by immunohistochemical expression of CD31 in 74 samples (63 primary and 11 recurrent samples, 63 patients) of sporadic desmoid tumours without familial adenomatous polyposis (FAP). β-catenin gene mutation and mRNA expression of VEGF was then examined by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). There was a statistically significant correlation between widespread nuclear expression of β-catenin and overexpression of VEGF in all desmoid tumours (P=0.04, Fisher's exact test). MVD in recurrent tumours was significantly higher than that in primary tumours. Conclusions: Abnormalities of β-catenin and VEGF overexpression play an important role in the neoplastic progression of sporadic desmoid tumours.
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U2 - 10.1111/j.1365-2559.2011.03945.x
DO - 10.1111/j.1365-2559.2011.03945.x
M3 - Article
C2 - 22034877
AN - SCOPUS:80053326434
VL - 59
SP - 368
EP - 375
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 3
ER -