Abnormally shaped arteries in the intestine of Children with Hirschsprung's disease: Etiological Considerations Relating to Ischemic Theory

Tomoaki Taguchi, Sachiyo Suita, Yuzo Hirata, Ryuichiro Hirose, Takaharu Yamada, Toshimitsu Toyohara

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Abnormally shaped arteries were found in the intestines of 17 of 62 patients (27%) with Hirschsprung's disease. The histological characteristics of abnormal arteries included proliferation of collagen fibers and smooth muscle cells in the adventitia. The incidence of abnormal arteries in each type of aganglionosis was as follows: 25% (13 of 51) in short-segment aganglionosis; 0% (0 of 6) in long-segment aganglionosis; and 80% (4 of 5) in total-colon or extensive aganglionosis. The older the patients were at the time of resection, the higher the incidence of abnormal arteries (<1 year old, 15%; 1-3 years old, 38%; >3 years old, 75%). The abnormally shaped arteries were mostly located in the histological transitional zone. These findings suggest the following possibilities: (a) the cran-iocaudal migration of ganglion cells was interrupted by intestinal ischemia in the presence of abnormal arteries in utero; (b) an ischemic episode caused both the disappearance of neural cells and dysplasia of the artery; (c) the ganglion cells were destroyed by mild ischemia caused by the abnormal arteries; or (d) the tension caused by mechanical expansion resulted in a change in the vascular walls in the transitional zone.

本文言語英語
ページ(範囲)200-204
ページ数5
ジャーナルJournal of pediatric gastroenterology and nutrition
18
2
DOI
出版ステータス出版済み - 2 1994

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 消化器病学

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