Absorption of 6- O -caffeoylsophorose and its metabolites in sprague-dawley rats detected by electrochemical detector-high-performance liquid chromatography and electrospray ionization-time-of-flight-mass spectrometry methods

Ju Qiu, Nozomi Saito, Mai Noguchi, Keiichi Fukui, Kayo Yoshiyama, Kazusato Matsugano, Norihiko Terehara, Toshiro Matsui

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Absorption and metabolism of a natural compound, 6-O-caffeoylsophorose (CS) from acylated anthocyanins in a red vinegar fermented with purple sweetpotato, were clarified. The absorption of CS and conjugated CS in blood from orally administrated Sprague-Dawley rats at a dose of 400 mg/kg was investigated by electrochemical detection-high performance liquid chromatography. As a result, CS was successfully detected in rat plasma (AUC0-6h, 108.6 ± 8.1 nmol h/mL) and was found to be an intact absorbable polyphenol. In addition, half of the absorbed CS was detected as its conjugates (AUC0-6h, 50.7 ± 5.7 nmol h/mL) as well as caffeic and ferulic acids from CS. By a time-of-flight-mass spectrometric analysis of CS-administered plasma sample, glucuronide and methylated conjugates of CS were identified, in addition to glucuronide, methylated, or sulfate conjugates of caffeic and ferulic acids. Consequently, CS was absorbed in intact form into rat blood and partly degraded to caffeic and ferulic acids or metabolized by glucuronidation, methylation, or sulfatation.

本文言語英語
ページ(範囲)6299-6304
ページ数6
ジャーナルJournal of Agricultural and Food Chemistry
59
11
DOI
出版ステータス出版済み - 6 8 2011

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

フィンガープリント 「Absorption of 6- O -caffeoylsophorose and its metabolites in sprague-dawley rats detected by electrochemical detector-high-performance liquid chromatography and electrospray ionization-time-of-flight-mass spectrometry methods」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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